Shanghai Aging Study

Principal Investigator

Dr. Ding Ding
Fudan University Huashan Hospital
Institute of Neurology
12 Middle Wulumuqi Rd
Shanghai 200040, China

Data Contact

Ding Ding


Setting: Jingansi community in downtown Shanghai, China
Start Date: 2010
End Date: Ongoing
Participants: 3141 individuals aged 60+ years
Assessment Schedule: Baseline and 4-year follow-up
Measures: (1) Sociodemographic data and lifestyle, including diet; (2) Medical history; (3) Neuropsychological test battery; (4) Clinical interview and neurological examination; (5) Physical measurements, blood and urine samples, APOE genotyping; (6) Anxiety, depression, sleep.

Further Information

  • Ding D. et al. The Shanghai Aging Study: Study Design, Baseline Characteristics, and Prevalence of Dementia (PDF). Neuroepidemiology. 2014;43:114-122. 
  • Wang F. et al. Elevated Fasting Blood Glucose Level Increases the Risk of Cognitive Decline Among Older Adults with Diabetes Mellitus: The Shanghai Aging Study (PDF). J Alzheimers Dis. 2019;67(4):1255-1265.
  • Ding D, Zhao Q, Guo Q, et al. Prevalence of mild cognitive impairment in an urban community in China: a cross-sectional analysis of the Shanghai Aging Study. Alzheimer’s & Dementia 2015;11:300-309
  • Liang X, Shan Y, Ding D, et al. Hypertension and High Blood Pressure Are Associated With Dementia Among Chinese Dwelling Elderly: The Shanghai Aging Study. Front. Neurol. 2018; 9:664. doi: 10.3389/fneur.2018.00664
  • Zhou F, Deng W, Ding D, et al. High Low-Density Lipoprotein Cholesterol Inversely Relates to Dementia in Community-Dwelling Older Adults: The Shanghai Aging Study. Front. Neurol. 2018; 9:952. doi: 10.3389/fneur.2018.00952 
  • Liang X, Chen Z, Dong X, et al. Mental work demands and late-life cognitive impairment: results from the Shanghai Aging Study. Journal of Aging Health 2018 Apr 1:898264318765034. doi: 10.1177/0898264318765034
  • Liang X, Ding D, Zhao Q, et al. Association between olfactory identification and cognitive function in community-dwelling elderly: the Shanghai Aging Study. BMC Neurology 2016; 16:199-207
  • Ding D, Zhao Q, Guo Q, et al. Progression and predictors of mild cognitive impairment in Chinese elderly: A prospective follow-up in the Shanghai Aging Study. Alzheimer’s & Dementia: diagnosis, assessment & disease monitoring 2016; 4: 28-36
  • Ding D, Xiong Y, Zhao Q, et al. White matter hyperintensity predicts the risk of incident cognitive decline in community dwelling elderly in China. Journal of Alzheimer's Disease 2018;61:1333-1341