COSMIC Publications

CHeBA Consortia - COSMIC
Cohort Studies of Memory in an International Consortium: An international consortium to combine data from population-based longitudinal cohorts studies to identify common risk factors for dementia and cognitive decline.




Free PMC Article


Sachdev et al. COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurol.  2013;13:165. 10.1186/1471-2377-13-165. PMID: 24195705. PMC3827845


Sachdev et al. The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC collaboration. PLOS One. 2015;10:e0142388. DOI: 10.1371/journal.pone.0142388. PMID:26539987. PMC4634954



Lipnicki et al. Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study. PLoS Med. 2017;14(3):e1002261. DOI: 10.1371/journal.pmed.1002261. PMID:28323832. PMC5360220

4 Jang et al. Differential effects of completed and incomplete pregnancies on the risk of Alzheimer disease. Neurology. 2018;91(7):e643-e651. Neurology. 2018;91(7):e643-e651 (PFD). DOI:10.1212/WNL.0000000000006000. PMID:30021919. PMC9811944 PMC9811944
5 Oltra-Cucarella et al. Visual memory tests enhance the identification of amnestic MCI cases at greater risk of Alzheimer’s disease. Int Psychogeriatr. 2018 Oct 25:1-10. DOI: 10.1017/S104161021800145X. PMID:30355384. PMC6483891 PMC6483891
6 Lipnicki et al. Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study. PLoS Med. 2019;16:e1002853. DOI: 10.1371/journal.pmed.1002853. PMID:31335910. PMC6650056 PMC6650056
7 Maasakkers et al. The association of sedentary behaviour and cognitive function in people without dementia: A coordinated analysis across five cohort studies. Sports Med. 2020 Feb;50(2):403-413. DOI: 10.1007/s40279-019-01186-7. PMID: 31529300. PMC6985182 PMC6985182
8 Turana et al. Factors associated with odour identification in older Indonesian and white Australian adults. Aging Clin Exp Res. 2020 Feb;32(2):215-221. DOI: 10.1007/s40520-019-01419-9. PMID:31755024. PMC7519881 PMC7519881
9 Makkar et al. APOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline. J Gerontol A Biol Sci Med Sci. 2020 May 12;glaa116. DOI: 10.1093/gerona/glaa116. PMID:32396611. PMC7518559 PMC7518559
10 Makkar et al. Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment. Arch Gerontol Geriatr. 2020 Jul 13;91:104112. DOI:10.1016/j.archger.2020.104112. PMID:32738518. PMC7724926 PMC7724926
11 Bae et al. Does parity matter in women’s risk of dementia?: a COSMIC collaboration cohort study. BMC Med. 2020 Aug 5;18(1):210. doi: 10.1186/s12916-020-01671-1. DOI:10.1186/s12916-020-01671-1. PMID:32753059. PMC7406389 PMC7406389
12 Carles et al. A Cross-National Study of Depression in Pre-clinical Alzheimer’s Disease: a COSMIC Collaboration Study. Alzheimers Dement. 2020 Sep 3. doi: 10.1002/alz.12149. DOI: 10.1002/alz.12149. PMID: 32881298. PMC7666102 PMC7666102
13 Bae et al. Parity and the risk of incident dementia: a COSMIC collaboration cohort study. Epidemiol Psychiatr Sci. 2020 Oct 20;29:e176. DOI: 10.1017/S2045796020000876. PMID:33077022. PMC7681107 PMC7681107
14 Roehr et al. Estimating prevalence of subjective cognitive decline across international cohort studies of ageing: A COSMIC study. Alzheimers Res Ther. 2020;12(1):167. DOI: 10.1186/s13195-020-00734-y. PMID: 33339532. PMC7749505 PMC7749505
15 Hyun et al. Education, occupational complexity, and incident dementia: A COSMIC collaborative cohort study. J Alzheimers Dis. 2021 Nov 11. doi: 10.3233/JAD-210627. DOI: 10.3233/JAD-210627. PMID: 34776437. PMC8748312 PMC8748312
16 Wu et al. Dose-response relationship between late-life physical activity and incident dementia: a pooled analysis of 10 cohort studies of memory in an international consortium. Physical activity and cognitive decline in older adults. Alzheimers Dement. 2022 Mar 15. doi: 10.1002/alz.12628. Online ahead of print. DOI: 10.1002/alz.12628. PMID: 35290713. PMC9652610  PMC9652610 
17 Mewton et al. The relationship between alcohol use and dementia in adults aged over 60 years: A combined analysis of prospective, individual-participant data from 15 international studies. Addiction. 2023;118(3):412-424. doi: 10.1111/add.16035. PMID: 35993434. PMC9898084 PMC9898084
18 Samtani et al. Associations between social connections and cognition: a global collaborative individual participant data meta-analysis. Lancet Healthy Longev. 2022 Nov;3(11):e740-e753. DOI: 10.1016/S2666-7568(22)00199-4. Epub 2022 Oct 20. PMID: 36273484. PMC9750173 PMC9750173
19 Gong et al. Sex differences in dementia risk and risk factors: individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium. Alzheimers Dement. 2023;19(8):3365-3378. DOI: 10.1002/alz.12962. PMID:36790027. PMC10955774 PMC10955774
20 Lipnicki et al. Harmonizing ethno-regionally diverse datasets to advance the global epidemiology of dementia. Clin Geriatr Med. 2023 February ; 39(1): 177–190. DOI:10.1016/j.cger.2022.07.009. PMID: 36404030. PMC: 9767705 PMC9767705
21 Mahalingam, Samtani et al. Social connections and risk of incident mild cognitive impairment, dementia and mortality in 13 longitudinal cohort studies of ageing. Alzheimers Dement. 2023;19(11):5114-5128. DOI: 10.1002/alz.13072. PMID:37102417. PMC10603208 PMC10603208
22 Sprague et al. Correlates of gait speed among older adults from six countries: Findings from the COSMIC collaboration. J Gerontol A Biol Sci Med Sci. 2023;78(12):2396-2406. DOI: 10.1093/gerona/glad090. PMID: 36975099. PMC10692426 PMC10692426
23 Oh et al. Parental History of Dementia and the Risk of Dementia: A cross-sectional analysis of a global collaborative study. Psychiatry and Clinical Neurosciences 2023 Aug;77(8):449-456. DOI: 10.1111/pcn.13561. PMID: 37165609. PMC10524874 PMC10524874
Available on 2024-08-01
24 Lennon et al. Use of Antihypertensives, Blood Pressure, and Estimated Risk of Dementia in Late -Life: An Individual Participant Data Systematic Review and Meta-Analysis. JAMA Netw Open. 2023 Sep 5;6(9):e2333353. DOI:10.1001/jamanetworkopen.2023.33353. PMID: 37698858. PMC10498335 PMC10498335
25 Lin et al. Risk factors and cognitive correlates of white matter hyperintensities in ethnically diverse populations without dementia: the COSMIC consortium. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (accepted 2024 Feb 2). DOI: 10.1002/dad2.12567. PMID: 38487075. PMC10937819 PMC10937819
26 Van Asbroeck et al. Lifestyle and incident dementia: A COSMIC individual participant data meta‐analysis. Alzheimers Dement. 2024 Apr 27. DOI: 10.1002/alz.13846. PMID: 38676366 PMC38676366