COSMIC Projects

COSMIC (Cohort Studies of Memory in an International Consortium) aims to bring together cohort studies of cognitive ageing internationally in order to facilitate a better understanding of the determinants of cognitive ageing and neurocognitive disorders.

Current Projects

1.       The impact of reproductive experiences on the risks of cognitive decline and dementia in older women.

a.     Aims: To compare how pregnancy with childbirth and lost pregnancy affect future cognitive decline and dementia.
b.     Leaders: KLOSCAD (Korean Longitudinal Study on Cognitive Aging and Dementia).
c.     Contributing studies: KLOSCAD (Korea), HELIAD (Greece), ESPRIT (France), MYNAH (India), and ZARADEMP (Spain).


2.       Olfactory ability and language test performance in Indonesian and Australian cohorts.

a.     Aims: To investigate how olfactory ability and other factors affect language function and MMSE scores in both an Indonesian and an Australian cohort.
b.     Leaders: ACtive Aging Research (Atma Jaya Cognitive & Aging Research).
c.     Contributing studies: ACtive Aging Research (Indonesia) and  Sydney MAS (Australia).


Completed Projects

1.        The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration(2014). 

a.       We analysed pooled data from 11 international cohort studies and found that applying uniform criteria to harmonized data greatly reduced the previously reported variation in mild cognitive impairment prevalence internationally.
b.      Published in PLOS One. 2015 Nov 5;10(11):e0142388.
2.       Age-related cognitive decline and effects of sex, education and apolipoprotein E genotype in diverse ethno-cultural and geographical regions internationally (2016).
a.       We used individual participant-level data to investigate rates of cognitive decline in 14 longitudinal population-based studies of cognitive aging, representing 12 countries and 5 continents. We also investigated the extent to which sex, education, and apolipoprotein E ε4 allele carrier status influenced cognitive performance and decline across these diverse ethno-cultural and geographic regions. Cognitive performance and decline was assessed using scores from the MMSE, and from tests of verbal memory, processing speed, language, and executive functioning.
b.      Preliminary results show that all cognitive measures decline with age, and the rate of decline increases at advanced age.  However, this rate is not the same in all countries and ethnic groups. Higher levels of education slowed the rate of decline on the MMSE, suggesting that higher education could protect against or delay the onset of dementia.
c.      A paper with full details of our analyses is currently under review at PLOS Medicine.


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