COSMIC Projects

COSMIC (Cohort Studies of Memory in an International Consortium) aims to bring together cohort studies of cognitive ageing internationally in order to facilitate a better understanding of the determinants of cognitive ageing and neurocognitive disorders.

Current Projects

Risk factors for cognitive decline across diverse ethnocultural groups and geographic regions.
a.    Aims: To investigate and compare associations between various risk factors (including medical conditions, mental health, and lifestyle) and cognitive decline in diverse ethnocultural groups and geographic regions.
b.    Leaders: CHeBA COSMIC team (Darren Lipnicki)
c.    Contributing studies (20, from 15 countries): Bambui (Brazil), CFAS (UK), CHAS (Cuba), EAS (USA), ESPRIT (France), HELIAD (Greece), HK-MAPS (Hong Kong), Invece.Ab (Italy), KLOSCAD (South Korea), LEILA75+ (Germany), MAAS (The Netherlands), MoVIES (USA), PATH (Australia), SALSA (USA), SPAH (Brazil), SGS (Japan), SLASI (Singapore), Sydney MAS (Australia), Tajiri Project (Japan), ZARADEMP (Spain).
d.    Follows on from Completed project #2; harmonisation of new member study data began in May 2017.
e.    Focussed investigations of associations between cognitive decline and each of body mass index, APOE4 status, and education are also being conducted.
The impact of reproductive experiences on the risks of cognitive decline and dementia in older women.
a.     Aims: To compare how pregnancy with childbirth and lost pregnancy affect future cognitive decline and dementia.
b.     Leaders: KLOSCAD (Korean Longitudinal Study on Cognitive Aging and Dementia).
c.     Contributing studies: KLOSCAD (Korea), HELIAD (Greece), ESPRIT (France), MYNAH (India), and ZARADEMP (Spain).
d.     Reproductive experiences: Began February 2016.
Olfactory ability and language test performance in Indonesian and Australian cohorts.
a.     Aims: To investigate how olfactory ability and other factors affect language function and MMSE scores in both an Indonesian and an Australian cohort.
b.     Leaders: ACtive Aging Research (Atma Jaya Cognitive & Aging Research).
c.     Contributing studies: ACtive Aging Research (Indonesia) and  Sydney MAS (Australia).
d.     Olfactory ability: Began April 2016.
Are visual-only memory impairments sufficient to diagnose amnestic MCI?
a.    Aims: To compare the risk of progression to dementia between amnestic mild cognitive impairment (aMCI) that is visual-only and aMCI that is verbal-only or combined verbal-visual.
b.    Leaders: Javier Oltra (University of Alicante, Spain).
c.    Contributing studies: EAS (USA), HELIAD (Greece), Invece.Ab (Italy), KLOSCAD (South Korea), Sydney MAS (Australia).
d.    Began December 2016.
MINDSED: The effects of sedentary behavior on cognitive function and cognitive decline in older persons without dementia.
a.    Aims: To determine if total sedentary time per day and/or length of unbroken sitting time, is cross-sectionally and prospectively related to global cognition and neuropsychological test scores in older persons without dementia who are cognitively healthy or have MCI?
b.    Leaders: Rene Melis (Radboud University, The Netherlands).
c.    Contributing studies: HELIAD (Greece), PATH (Australia), SLAS2 (Singapore), SGS (Japan), SALSA (USA).
d.    Began June 2017.
The prevalence of subjective cognitive decline across and in different geographical and ethno-cultural regions.
a.    Aims: To establish the prevalence of subjective cognitive decline (SCD) in and across different geographical and ethno-cultural regions.
b.    Leaders: Susanne Roehr (LEILA75+, Germany)
c.    Contributing studies: ACtive Aging (Indonesia), CFAS (UK), EAS (USA), ESPRIT (France), Invece.Ab (Italy), KLOSCAD (Korea), LEILA75+ (Germany), LRGS TUA (Malaysia), MAAS (The Netherlands), MoVIES (USA), PATH (Australia), SGS (Japan), SLAS2 (Singapore), Sydney MAS (Australia), ZARADEMP (Spain).
d.     Data harmonisation and analyses began February 2018

Completed Projects

The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration(2014). 
a.    We analysed pooled data from 11 international cohort studies and found that applying uniform criteria to harmonized data greatly reduced the previously reported variation in mild cognitive impairment prevalence internationally.
b.      Published in PLOS One. 2015 Nov 5;10(11):e0142388.
Age-related cognitive decline and effects of sex, education and apolipoprotein E genotype in diverse ethno-cultural and geographical regions internationally (2016).
a.      We used individual participant-level data to investigate rates of cognitive decline in 14 longitudinal population-based studies of cognitive aging, representing 12 countries and 5 continents. We also investigated the extent to which sex, education, and apolipoprotein E ε4 allele carrier status influenced cognitive performance and decline across these diverse ethno-cultural and geographic regions. Cognitive performance and decline was assessed using scores from the MMSE, and from tests of verbal memory, processing speed, language, and executive functioning.
b.      Performance on all cognitive measures declined with age, and the rate of decline increased with advancing age.  However, rates of decline were not the same in all countries and ethnic groups. Higher levels of education slowed the rate of decline on the MMSE, suggesting that higher education could protect against or delay the onset of dementia.
c.      Published in PLoS Med 14(3): e1002261.

Approved Projects

Application of statistical methods accounting for missing data to elucidate the role of APOE2 on aging and Alzheimer's Disease: a meta-analysis of data from the COSMIC consortium of longitudinal studies.
a.    Aims:
        i.    Evaluate the effect of ApoE2 on aging and AD by modeling its effect on cognitive decline using mixed effects models, incident AD and death using multi-state models, taking account of non-random drop out by joint   modeling with auxiliary information on cognition, and taking account of missing data in ApoE using multiple imputation approach.
       ii.    Examine whether certain cardiometabolic risk factors mediate the effect of ApoE2 on aging and AD, taking account of non-random drop out by joint modeling with auxiliary information on cognition, and taking account of missing data in ApoE and cardiometabolic risk factors using multiple imputation approach.
b.    Leaders: Mindy Katz & Cuiling Wang (EAS, USA).
c.    Approved January 2017; to begin late 2017
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