Study of Factors Influencing Post-Stroke Dementia (STROKDEM)

Principal Investigator

Regis Bordet
Department of Pharmacology,
University of Lille,
U1171, 59045 Lille, France.


Country France
Principal Investigator Régis Bordet
Contact person (email)
Key publication/reference NCT01330160
Years in which study conducted 2011-
Size 195
Population: Hospital/community Hospital
Selection: consecutive/random Consecutive
Admit with previous stroke? Yes
Admit with TIA? Yes
Age range >40 years
Number of centres 2 (Lille, Rouen) + link to German centers through DEMDAS study
Control group: number, population, selection No
Initial: Time and data collected/tests administered Within 72 hours: MedHx, VRF, MRI, blood analyses, MoCa, MMSE, IQCODE
Detailed (initial)
Subsequent (follow-ups) 6m, 12m, 36m, 60m: NΨ, biological samples, MRI
Stroke-related data NIHSS, TOAST, ASCOD
Functional tests/data Modified Rankin Scale, Barthel Index
Other medical tests/data Plasma biomarkers (vascular, inflammation, trophic factors, AD markers); DNA
Neuropsychological tests Test battery



MRI scans, when and how many MRI  initial, 6m, 36m ,60m
PET scans At 12m (small number of selected patients)
Psychiatric exams/diagnoses Dementia, CDR, depression  (CES-D), apathy (Lille Apathy Rating Scale), anxiety (Hamilton Anxiety Scale)
Intervention trialled? No

CT=computed tomography scan, MedHx=medical history, VRF=vascular risk factors (hypertension, diabetes, atrial fibrillation, obesity, smoking etc.), NΨ=neuropsychological, TIA=transient ischemic attack, m=month, y=year