Prevention Of Decline in Cognition After Stroke Trial (PODCAST)

Principal Investigator

Professor Philip Bath
Nottingham City Hospital
Hucknall Road


Country UK
Principal Investigator Professor Philip M Bath
Contact person (email)
Key publication/reference Bath et al. PLoS One 2017; 12(1):e0164608
Years in which study conducted 2010-2014
Size 83
Population Hospital
Selection Consecutive
Admit with previous stroke? Yes
Admit with TIA? No
Age range 60+
Number of centres 19
Control group: number, population, selection Randomised partial factorial trial in patients with recent stroke.
No normal/community population
Initial: Within 7 months: medical history, function, VRF, t-MMSE
First detailed assessment
  • Clinical: ACE-R, MMSE, MoCA, TICS, Trails A+B, Stroop, IQ-CODE, verbal fluency (animal)
  • Telephone: MMSE, TICS
  • Clinical: 6, 18 months
  • Telephone: 12 months
Stroke-related data
  • Type (CT scan), impairment (NIH Stroke Scale), IS cause
  • Vascular risk factors (hypertension, diabetes, IHD, atrial fibrillation, obesity, smoking, alcohol)
Functional tests/data Disability (Barthel index), dependency (modified Rankin Scale), quality of life (EQ-5D, EQ-VAS)
Other medical tests/data
  • Blood pressure
  • Lipids (TC, TG, HDL, calculated LDL)
Neuropsychological tests No more than above
MRI scans, when and how many None
PET scans None
Psychiatric exams/diagnoses Mood (Zung depression scale)
Dementia diagnosis criteria DSM IV
Intervention trialled?
  • Intensive vs guideline BP lowering
  • Intensive vs guideline lipid lowering

CT=computed tomography scan. VRF=vascular risk factors