Mild Stroke Study II (MSS-II)

Principal Investigators

Professor Joanna Wardlaw, MD, FRCR, FRCP, FMedSci, FRSE
Professor of Applied Neuroimaging and Honorary Consultant Neuroradiologist
Head of Division, Neuroimaging Sciences
Director, Brain Research Imaging Centre, Edinburgh Imaging
Centre for Clinical Brain Sciences
Chancellor’s Building
49 Little France Crescent, Edinburgh, EH16 4SB, UK


Country UK
Principal Investigator Joanna Wardlaw
Contact person (email)
Key publication/reference Heye et al (2015), Heye et al (2016), Valdes Hernanadez et al (2015)
Years in which study conducted 2010-2015
Size 264
Population: Hospital/community Hospital
Selection: consecutive/random Consecutive
Admit with previous stroke? Yes
Admit with TIA? No
Age range Late 30s to 90s
Number of centres 1
Control group: number, population, selection No
Initial: Time and data collected/tests administered <2 weeks of stroke
Detailed Subsequent (follow-ups) 1-3 months, 1 yr, 3 yr
Stroke-related data YES
Functional tests/data MRS
Other medical tests/data Medical Testing
Neuropsychological tests Yes
MRI scans, when and how many Baseline, 1-3months, 1 yr
PET scans No
Psychiatric exams/diagnoses Beck Depression Index
Intervention trialled? Yes / No

Further Information:

Valdés Hernández MC, Armitage PA, Thrippleton MJ, Chappell F, et al. Rationale, design and methodology of the image analysis protocol for studies of patients with cerebral small vessel disease and mild stroke, Brain and Behavior, 2015; 5(12), e00415, doi: 10.1002/brb3.415 (

Heye AK, Thrippleton MJ, Chappell FM, Valdés Hernández MD, et al. J Cereb Blood Flow Metab. 2015 Apr 22. doi: 10.1038/jcbfm.2015.64. (

Heye AK, Thrippleton MJ, Armitage PA, Valdés Hernández MD C, et al. Neuroimage. 2016 Jan 15;125:446-55. doi: 10.1016/j.neuroimage.2015.10.018. (