Groupe de Réflexion pour l'Evaluation COGnitive VASCulaire study (GRECog-Vasc study)

Principal Investigator

Pr Olivier Godefroy
Service de Neurologie
CHU Amiens
80054 Amiens Cedex


Country France
Principal Investigator Prof. Olivier Godefroy
Contact person (email)
Key publication/reference Godefroy O, et al. Int J Stroke. 2012; 7:362-3.
Years in which study conducted 2010-5 (AV45 PET substudy on-going)
Size 360
Population: Hospital/community Hospital
Selection: consecutive/random Consecutive
Admit with previous stroke? Yes
Admit with TIA? No
Age range 40-80
Number of centres 4
Control group: number, population, selection French healthy controls (n=1003)
Assessment  <
Initial: Time and data collected/tests administered MedHx, VRF, clinical, stroke characteristics, IQCODE, MMSE-MoCA,
Detailed 6m:clinical, NΨ,psychiatric
Subsequent (follow-ups) 1/yrs according to status
Stroke-related data NIHSS, ASCO, MRI
Functional tests/data Rankin, Barthel, IADL, DAD (subsample)
Other medical tests/data HMPAo SPECT or/and CSF biomarkers when clinically indicated
Neuropsychological tests French adaptation of Harmonization SP
MRI scans, when and how many MRI at 6m (and if possible initially)
PET scans AV45 PET in CI subsample (planned: n=100)
Psychiatric exams/diagnoses Depression (CESDS); anxiety (Goldberg); NPI; Dysexecutive Behavior (Behavioral Dysexecutive Syndrome Inventory) Dementia (DSM-V), VaD, VCI,
Intervention trialled? No

CT=computed tomography scan, MedHx=medical history, VRF=vascular risk factors (hypertension, diabetes, atrial fibrillation, obesity, smoking etc.), NΨ=neuropsychological, TIA=transient ischemic attack, m=month, y=year