Determinants of Dementia After Stroke (DEDEMAS)

Principal Investigator

Martin Dichgans
Institut für Schlaganfall- und Demenzforschung (ISD),
Klinikum der Universität München,
Feodor-Lynen-Straße 17,
D-81377 München, Germany.


Country Germany
Principal Investigator Martin Dichgans
Contact person (email)
Key publication/reference Wollenweber et al. Int J Stroke 2014;9:387-392
Years in which study conducted 2011-2019
Size 600 (intended)
Population: Hospital/community Hospital
Selection: consecutive/random Consecutive
Admit with previous stroke? Yes
Admit with TIA? No
Age range 18+
Number of centres 1
Control group: number, population, selection No
Initial: Time and data collected/tests administered Within 3 days: VRF, MedHx, function, MRI, MMSE, MoCA, IQCODE, blood analyses
Detailed 6m: NΨ, function, depression, CDR
Subsequent (follow-ups) 3m, 2y, 4y: TICS, function
Stroke-related data NIHSS, TOAST
Functional tests/data Modified Rankin Scale, Barthel Index, IADLs
Other medical tests/data DNA, RNA, plasma, serum, CSF
Neuropsychological tests CERAD-Plus, test battery
MRI scans, when and how many Initial, 6m, 3y, 5y
PET scans Amyloid and FDG in patients with incident dementia or cognitive decline
Psychiatric exams/diagnoses Dementia, depression (CES-D), CDR
Intervention trialled? No

CT=computed tomography scan, MedHx=medical history, VRF=vascular risk factors (hypertension, diabetes, atrial fibrillation, obesity, smoking etc.), NΨ=neuropsychological, TIA=transient ischemic attack, m=month, y=year