Cognitive Outcome After Stroke (COAST)

Principal Investigators

Christopher Chen, Catherine Dong
Contact: Christopher Chen (
Memory Ageing and Cognition Centre


Country Singapore
Principal Investigators Christopher Chen, Catherine Dong
Contact person (email)
Key publication/reference Dong et al. J Neurol  Neurosurg Psychiatr2012;83:580-85
Years in which study conducted 2009- 
Size 400
Population: Hospital/community Hospital
Selection: consecutive/random Consecutive
Admit with previous stroke? Yes
Admit with TIA? Yes
Age range Mean=60.2
Number of centres 1
Control group: number, population, selection From other studies
Initial: Time and data collected/tests administered Within 2 weeks: MedHx, MMSE, MoCA, IQCODE, CT, MRI
Detailed 3-6m: neurological status, clinical outcomes, NΨ
Subsequent (follow-ups) 1y, 5y, 6y, 7y (same as 3-6m)
Stroke-related data NIHSS, TOAST
Functional tests/data Modified Rankin Scale, Bayer ADL
Other medical tests/data TCD data (<1/3 of the patients)
Neuropsychological tests Test battery
MRI scans, when and how many 97
PET scans No
Psychiatric exams/diagnoses Depression (GDS)
Intervention trialled? No

CT=computed tomography scan, MedHx=medical history, VRF=vascular risk factors (hypertension, diabetes, atrial fibrillation, obesity, smoking etc.), NΨ=neuropsychological, TIA=transient ischemic attack, m=month, y=year