Cognition and Neocortical Volume After Stroke (CANVAS) Study

Principal Investigator

Amy Brodtmann
Behavioural Neuroscience,
Florey Institute for Neuroscience and Mental Health,
Melbourne Brain Centre,
245 Burgundy Street
Heidelberg 3084, Australia.


Country Australia
Principal Investigator Amy Brodtmann
Contact person (email)
Key publication/reference Brodtmann et al. Int J Stroke 2014;9:824-828
Years in which study conducted 2014-2017
Size 135 (intended)
Population: Hospital/community Hospital
Selection: consecutive/random ?
Admit with previous stroke? ?
Admit with TIA? ?
Age range 18+
Number of centres 3 (Melbourne hospital stroke units)
Control group: number, population, selection N=40, from prior MRI studies and appropriate family members
Initial: Time and data collected/tests administered Within 1m after stroke: MedHx, VRF, function, brief NΨ, IQCODE
Detailed 3m: function, IQCODE, brief NΨ, extended NΨ
Subsequent (follow-ups) 12m, 36m: same as 3m plus CDR, SASNOS
Stroke-related data NIHSS
Functional tests/data Modified Rankin scale, SASNOS
Other medical tests/data APO genotyping, general health, blood pressure, cholesterol
Neuropsychological tests Brief: test battery including NART and MoCA
Extended: test battery covering 5 domains
MRI scans, when and how many 0, 3, 12, 36m
PET scans Amyloid in subgroup at 36m
Psychiatric exams/diagnoses Anxiety (GAD-7), CDR
Intervention trialled? No

CT=computed tomography scan, MedHx=medical history, VRF=vascular risk factors (hypertension, diabetes, atrial fibrillation, obesity, smoking etc.), NΨ=neuropsychological, TIA=transient ischemic attack, m=month, y=year