Cognition and Affect after Stroke: Prospective Evaluation of Risks (CASPER)

Principal Investigators

Sebastian Köhler, Pauline Aalten, Frans Verhey
Contact: Seb Köhler
School for Mental Health and Neuroscience,
Department of Psychiatry and Neuropsychology,
Maastricht University, The Netherlands.


Country The Netherlands
Principal Investigators Seb Köhler, Pauline Aalten, Frans Verhey
Contact person (email)
Key publication/reference Douven et al. BMC Neurology 2016; 16:65
Years in which study conducted 2013-2016
Size 250
Population: Hospital/community Hospital
Selection: consecutive/random Consecutive
Admit with previous stroke? Yes, if fully remitted, no residual symptoms
Admit with TIA? Yes
Age range 40+
Number of centres 1
Control group: number, population, selection None; cognition data are z-scores based on norm groups for age, gender and education from the Maastricht Aging Study
Initial: Time and data collected/tests administered 3m after index stroke (baseline)
Detailed 3m after index stroke (baseline)
Subsequent (follow-ups) 6m after baseline (9m after stroke), 12m after baseline (15m after stroke)
Stroke-related data Location, severity, volumetry
Functional tests/data Barthel (ADL), Lawton (IADL), SS-QoL,
Other medical tests/data MedHx; VRF; Immune function and inflammation (e.g. hsCRF, IL-6, TNF-a, sICAM, sVCAM, sE/sP-selectine); tHcy, folate, vit B12; standard lab; DNA buffycoats (e.g. ApoE, ACE, MTHFR); PAXgene tubes (RNA)
Neuropsychological tests MMSE, Rey 15 Word Verbal Learning Test, Digit Span, Digit Substitution Test, TMT A and B, BADS Zoo & Key Search, Verbal Fluency, Clock drawing, Star cancellation, Boston Naming Test, Dutch Adult Reading Test
MRI scans, when and how many Yes (3T; T1, T2, T2*/DWI, SWI, FLAIR) at baseline, with volumetry for stroke lesion (manual), WML (semi-auomatic, Rotterdam pipeline), hippocampus (LEAP); Fazekas and MTA visual rating scales
PET scans No
Psychiatric exams/diagnoses DSM-IV depression (MINI), dementia, NPI, MADRS, HADS, AES, Fatigue Severity Scale, NEO-FFI (personality)
Intervention trialled? No

CT=computed tomography scan, MedHx=medical history, VRF=vascular risk factors (hypertension, diabetes, atrial fibrillation, obesity, smoking etc.), NΨ=neuropsychological, TIA=transient ischemic attack, m=month, y=year