The Older Australian Twins Study is a longitudinal study investigating healthy brain ageing in older twins (65+ years). Healthy ageing is characterised by low levels of disability, high cognitive and functional capacity, and an active engagement in life. The most important ingredient of healthy ageing is a healthy brain, bereft of age-related diseases and dysfunction. Brain ageing and brain diseases are determined by multiple genetic factors that interact with environmental influences. Since identical twins share 100% of their genes, whereas non-identical twins share half the genetic information, detailed comparisons of these two groups has the potential to discover new genes involved in cognitive decline or resilience.
OATS commenced in New South Wales in January 2007, in Queensland in December 2007, and in Victoria in February 2008. Since the OATS study started we have followed our twin volunteers up every two years to check on their psychological and physical health. Participants undergo rigorous medical and cognitive function tests, with many participants also providing bloods samples and having a magnetic resonance imaging (MRI) scan of their brain. OATS assessed 623 participants at baseline, 450 at the 2-year follow up, and 390 completed their 4-year follow-up.
We are currently finishing an OATS imaging sub-study investigating the deposition of amyloid plaques in the brain using positron emission tomography (PET) scans. Amyloid plaques are thought to predict memory decline with age. Performing these scans in twins will help us to establish how these amyloid plaques relate to performance in memory and thinking ability. We also aim to determine if there is a genetic component, and if there are any potentially modifiable environmental factors that may be contributing to the development of the plaques. For this sub-study, 207 participants in New South Wales and Victoria were assessed and scanned.
The OATS Study has collected a unique data set from which we can examine genetic and environmental influences on a range of ageing-related issues. In particular we are investigating links between cognitive function and brain chemistry over time which has not been looked at previously. The diversity and depth of our work has also allowed us to form collaborative partnerships with other twin studies around the world. These collaborations are important as we have the opportunity to further enlarge our sample size and thereby better address genetic questions, which require large samples.
The OATS aims to find out what influences memory and thinking as we age. It investigates environmental influences such as lifetime physical and mental activity, socioeconomic environment, and nutrition. It also investigates how biological factors such as hypertension and antioxidant levels interact with genes to influence brain ageing. Since, over time, the expression of genes varies depending on different influences in the environment, by studying twins, OATS aims to determine which influences on the ageing process are genetic, which are environmental, and how the two interact.
For all CHeBA publications, see Publications.
|Sachdev PS, Lammel A, Trollor JN, Lee T, Wright MJ, Ames D, et al.||A comprehensive neuropsychiatric study of elderly twins: the Older Australian Twins Study.||Twin Res Hum Genet., 2009;12(6):573-582. doi.org/10.1375/twin.12.6.573|
|Sachdev PS, Lee T, Wen W, Ames D, Batouli AH, Bowden J, et al.||The contribution of twins to the study of cognitive ageing and dementia: the Older Australian Twins Study.||Int Rev Psychiatry, 2013;25(6):738-747. doi.org/10.3109/09540261.2013.870137|
|Koncz R, Mohan A, Dawes L, Thalamuthu A, Wright M, Ames D, et al.||Incidental findings on cerebral MRI in twins: the Older Australian Twins Study||Brain Imaging and Behavior, 2018 June;12(3):860–869. doi.org/10.1007/s11682-017-9747-2|
|Lee T, Thalamuthu A, Henry JD, Trollor J, Ames D, Wright MJ, Sachdev PS, OATS Research Team||Genetics and environmental influences on language ability in older adults: Findings from the Older Australian Twins Study.||Behavior Genetics, 2018 May;48(3):187-197. doi.org/10.1007/s10519-018-9897-z|
Course type Student Supervisor(s) University PhD Liliana Ciobanu Berhard Baune, Catherine Toben Uni Adelaide PhD Jess Lazarus Karen Mather, John Kwok (NeuRA) UNSW PhD Helen Wu Karen Mather, Perminder Sachdev, Henry Brodarty UNSW PhD Annette Spooner Perminder Sachdev, Arcot Sowmya UNSW PhD Andrea Lammel Perminder Sachdev Macquarie Honours Emily Hartman Katherine Samaras University of Notre Dame PhD Rebecca Koncz Perminder Sachdev UNSW PhD Ruby Tsang Karen Mather UNSW MSc Maboobeh Hosseini Anne Poljak UNSW PhD Matthew Wong Anne Poljak UNSW
Title Student Supervisor(s) University Year Heritability of Excessive Daytime Sleepiness and Associated Inflammation in Older Australian Twins Tanya Duckworth Julian Troller, Greg Roach CQU CQU, Honours 2012 Genetic and Environmental Influences on Neuropsychological Functioning in Later Life: The Older Australian Twins Study Teresa Lee Perminder Sachdev University of NSW, PhD 2013 Genetic and Environmental Influences on Brain Structure and Biochemistry in the Elderly: Data from the Older Australian Twins Study S.A.H.Batouli Perminder Sachdev, Julian Trollor and Wei Wen University of NSW, PhD 2013 Examination of DNA Methylation in the APOA1 Gene Jessica Lazarus Karen Mather, John Kwok (NeuRA) University of NSW, Honours 2013 Genetics of the White Matter Integrity in the Ageing Brain Sri Chandana Kanchibhotla Karen Mather University of NSW, Masters 2015 The Relationships of Inflammation with Brain Structures in Older Individuals as Revealed by Multimodal Magnetic Resonance Imaging Techniques Jiyang Jiang Wei Wen, Julian Trollor, Perminder Sachdev UNSW, PhD 2016 Homocysteine Levels & May Be Depression, Dementia, Cognitive Performance, Neuroimaging Ng Wan Qi (Sandra) Karen Mather UNSW, ILP 2016 Brain Networks in Healthy Ageing and Psychiatric Conditions Alistair Perry Wei Wen, Perminder Sachdev, Michael Breakspear UNSW, PhD 2017
Professor David Ames
Professor Bernhard Baune
Professor Henry Brodaty
Dr John Crawford
Dr Teresa Lee
Professor Nick Martin
Dr Karen Mather
Professor Christopher Rowe
Professor Perminder Sachdev
Professor Katherine Samaras
Professor Peter Schofield
Professor Julian Trollor
Associate Professor Wei Wen
Associate Professor Margie Wright