Principal Investigator
Professor Qun Xu
Department of Neurology, Renji Hospital
Medical School of Shanghai Jiaotong University
No. 160 Pujian Road, Shanghai 200127
Summary
Country | China |
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Principal Investigator | Professor Qun Xu |
Contact person (email) | zhinanstudent@126.com |
Key publication/reference | Cao et al. Int Psychogeriatr. 2017; 29;793-803 Sun et al. Front Aging Neurosci. 2016 |
Years in which study conducted | Since 2012, mostly recruited since 2015 (62%) |
Sample | |
Size | 200 |
Population: Hospital/community | Hospital |
Selection: consecutive/random | Consecutive (since 2015) |
Admit with previous stroke? | Yes |
Admit with TIA? | No |
Age range | Inclusion criteria: 50–85 |
Number of centres | 1 |
Control group: number, population, selection | 52, community population, age, sex and education matched people with normal cognition and brain imaging |
Assessment | |
Initial assessment | Within 1 week: Med Hx , VRF, NIHSS |
First detailed assessment | At least 4 weeks after symptomatic stroke due to small vessel disease: NΨ covering attention, executive, memory, language and visuo-spatial function, MMSE and/or MoCA, HDRS |
Follow-ups | Every one year ( NΨ and MRI) for those with moderate or severe white matter lesions for 4 years (plan) |
Stroke-related data | VRFs, NIHSS |
Functional tests/data | MRS, ADL, IADL |
Other medical tests/data | Blood analysis |
Neuropsychological tests | NΨ |
MRI scans, when and how many | Within 1 week (screening MRI: T1, T2 Flair, DWI, MRA) and at least 4 weeks since stroke(research MRI: T1, T2 Flair, SWI, DTI, 3D-MPRAGE, fMRI) |
PET scans | No |
Psychiatric exams | Depression (Hamilton) |
Dementia diagnosis criteria | VCI diagnostic criteria suggested by Vascular Contributions to Cognitive Impairment and Dementia -A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (Stroke , 2011;42:2672-2713). |
Intervention trialled? | No |
VRF=vascular risk factors (hypertension, diabetes, hyperlipidemia, smoking etc.); NΨ=neuropsychological battery; Med Hx=medical history; MRS=Modify Rankin Scale