The Genomics & Epigenomics Group has grown out of our interest in gaining a greater insight into the genomic, epigenomic and transcriptomic factors contributing to healthy ageing, exceptional longevity, age-related decline and disease.
Our research aims to provides a greater understanding of the biological processes underlying human ageing. It will also assist in the early identification of individuals who are at greater risk of age-related decline, disability and disease and thereby target them for potential interventions. As epigenomic modifications are potentially modifiable by environmental factors, our research may suggest novel preventative or therapeutic strategies for altering epigenomic profiles in older adults to promote healthy ageing.
Our work began in 2005 when the first DNA samples were donated by participants from the Sydney Memory and Ageing Study. Since the arrival of Dr Karen Mather in 2009 and Dr Anbu Thalamuthu in 2012, the group has been able to expand its activities and now includes data from whole genome sequencing, genome-wide genotyping, gene expression (coding, non-coding) and DNA methylation. Additionally, establishment of collaborations with national and international investigators and consortia has enabled investigation of age-related questions on a larger scale.