Sydney Memory and Ageing Study

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Project Main Description: 

The Sydney Memory and Ageing Study (Sydney MAS) began in 2005 to examine the clinical characteristics and prevalence of mild cognitive impairment (MCI) and related syndromes, and to determine the rate of change in cognitive function over time.  It is one of the largest longitudinal studies of this kind in Australia and has resulted in more than 110 scientific publications and many national and international collaborations.

Design and Method: 

At the baseline assessment from 2005 to 2007, 1037 non-demented individuals aged 70-90 were recruited from two areas of Sydney, following a random approach to 8914 individuals on the electoral roll. They underwent detailed neuropsychological and medical assessments and donated a blood sample for clinical chemistry, proteomics and genomics. A knowledgeable informant was also interviewed. Structural MRI scans were performed on 544 of the participants, and subgroups participated in studies of falls and balance, metabolic and inflammatory markers, functional MRI and prospective memory. The group is followed up with brief telephone reviews annually and detailed assessments biannually.

The Sydney MAS methodology paper can be accessed here.

The Sydney MAS flow chart can be accessed here.

Findings

  • Older people in the Sydney Memory and Ageing Study are generally well-functioning, with most of them rating their general health as good to excellent, despite significant vascular morbidity observed in the sample.
  • Most participants (95.5%), or their informants, identified a cognitive difficulty at baseline. 43.5% of participants had impairment on at least one neuropsychological test.
  • The rate of MCI was relatively high in this population at baseline. Males had a significantly higher prevalence of MCI than females (40.5% vs. 33.7%).
  • Participants with MCI were more likely to develop dementia over the 2-year follow-up period than those without MCI.
  • Participants with current depressive symptoms or a history of depression at baseline had higher levels of psychological distress and anxiety, lower life satisfaction and showed poorer cognitive performance in memory and executive functioning.
  • Baseline depression was associated with subsequent dementia and baseline anxiety with subsequent MCI at 2-year follow-up.
  • Risk factors for developing MCI or dementia within a 6-year follow-up period included: increasing age, MCI at baseline, poorer smelling ability, being an APOE ε4 carrier and slower walking speed.  There was a considerable overlap between the risk factors for mortality and those for dementia.
  • Recent alcohol consumption (including “low consumption” and “risky consumption”) was not associated with incident dementia at 4-year follow-up. Carriers of the APOE ɛ4 allele were more likely to develop dementia, but there was no significant interaction with alcohol consumption.
  • Older adults’ performance on a test of reaction time indicated their likelihood of developing dementia. Individuals who had slower responses on a simple reaction time task were 2-3 times more likely to receive a diagnosis of dementia within four years.
  • Structural MRI distinguishes the brains of elderly individuals with ‘amnestic MCI’ from those classified as ‘cognitively normal’. Amnestic MCI was associated with smaller volumes of overall cortex, medial temporal structures, anterior corpus callosum and select frontal and parietal regions compared with brains from cognitively normal individuals.

 

Research Highlights:

  • Development and validation of a new assessment tool, the Sydney Test of Activities of Daily Living (STAM). The STAM is designed to objectively assess an older person’s level of independence in ‘Instrumental Activities of Daily Living’ such as managing medications, shopping and handling finances. The STAM can be used to differentiate between normal cognition, MCI, and dementia and can be a helpful tool for diagnostic classification both in clinical practice and research (Reppermund et al., 2016).

MAS Published Papers

In Press

Authors

Title

Journal

Hibar DP, et al.

Novel genetic loci associated with hippocampal volume

Naure. Commun., Jan 18; 8:13624.

 

Willems SM, et al.

Large-Scale GWAS Identifies Multiple Loci Associated with Hand Grip Strength and Provides New Insights into the Biology of Muscular Fitness

Nature Commun. Accepted 24/4/17

Lipnicki DM, Crawford JD, Dutta R, Thalamuthu A, Kochan NA, Andrews G, et al.

Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethno-cultural groups and geographic regions: a collaborative cohort study.

PLOS Medicine (In press)

Aerts L, Heffernan M, Kochan, NA, Crawford JD, Draper B, Trollor JN, Sachdev PS, Brodaty H.

Effects of MCI subtype and reversion on progression to dementia in a community sample

Neurology, published ahead of print on 10 May 2017.

Haynes BI, Bunce D, Kochan NA, Wen W, Brodaty H, Sachdev P.

Associations Between Reaction Time Measures and White Matter Hyperintensities in Very Old Age

Neuropsychologia 96, 249-255. 2017 Jan 21. 

Brodaty H, Aerts L, Crawford JD, Heffernan M, Kochan NA, Reppermund S, Kang K, Maston K, Draper B, Trollor JN, Sachdev PS.

Operationalizing the diagnostic criteria for mild cognitive impairment: the salience of objective measures in predicting incident dementia.

American Journal of Geriatric Psychiatry (in press).

Thompson C, Henry J, Sachdev P, Brodaty H, et al.

Prospective Memory Function and Cue Salience in Mild Cognitive Impairment. Findings from the Sydney Memory and Ageing Study.

Journal of Clinical and Experimental Neuropsychology (in press).

 

Lipnicki DM, Crawford J, Kochan NA, Trollor JN, Draper B, Reppermund S, Maston K, Mather KA, Brodaty H, Sachdev PS, and the Sydney Memory and Ageing Study Team

Risk factors for mild cognitive impairment, dementia and mortality: the Sydney Memory and Ageing Study.

Journal of the American Medical Directors Association (in press).

2016

Authors

Title

Journal

Reppermund S, Birch RC, Crawford JD, Wesson J, Draper B, Kochan NA, Trollor JN, Luttenberger K, Brodaty H, Sachdev PS.

Performance Based Assessment of Instrumental Activities of Daily Living - Validation of the Sydney Test of Activities of Daily Living in Memory Disorders (STAM).

Journal of the American Medical Directors Association. 2016, Oct 6. pii: S1525-8610(16)30359-0

Bunce D, Haynes BI, Lord SR, Gschwind YJ, Kochan NA, Reppermund S, Brodaty H, Sachdev PS and Delbaere K. 

Intra-individual stepping reaction time variability predicts falls in older adults with Mild Cognitive Impairment.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2016 Sep 3. pii: glw164

Woolf C, Slavin MJ, Draper B, Thomassen F, Kochan NA, Reppermund S, Crawford JD, Trollor JN, Brodaty H, Sachdev PS.

Can the Clinical Dementia Rating Scale Identify Mild Cognitive Impairment and Predict Cognitive and Functional Decline?

Dementia and Geriatric Cognitive Disorders. 2016; 41:292-302 

Mather KA, Thalamuthu A, Oldmeadow C, Song F, Armstrong NJ, Poljak A, Holliday EG, McEvoy M, Kwok JB, Assareh AA, Reppermund S, Kochan NA, Lee T, Ames D, Wright MJ, Trollor JN, Schofield PW, Brodaty H, Scott RJ, Schofield PR, Attia JR, Sachdev PS.

Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults.

Scientific Reports. 2016, 6:23675

Yang Z,Wen WJiang J,Crawford JDReppermund S,Levitan C,Slavin MJ,Kochan NA,Richmond RL,Brodaty H,Trollor JN, Sachdev PS.

Age-associated differences on structural brain MRI in non-demented individuals from 71 to 103 years.

Neurobiology of Aging. 2016, Apr; 40:86-97

Heffernan M, Mather K, Xu J, Assareh A, Kochan NA, Reppermund S, Draper B, Trollor JN, Sachdev P, Brodaty H.

Alcohol Consumption and Incident Dementia: Evidence from the Sydney Memory and Ageing Study.

Journal of Alzheimer’s Disease. 2016, Volume 52, Number 2

Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Thalamuthu A, Andrews G, et al. 

The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC collaboration.

PLOS ONE. 2016, 10(11): e0142388

Poljak A, Crawford JD, Smythe GA, Brodaty H, Slavin MJ, Kochan NA, Trollor JN, Wen W, Mather KA, Assareh AA.

 The relationship between plasma aβ levels, cognitive function and brain volumetrics: Sydney Memory and Ageing Study.

Current Alzheimer Research. 2016, vol. 13, pp. 243 - 255

Kochan NABunce DPont SCrawford JDBrodaty HSachdev PS.

Reaction time measures predict incident dementia in community-living older adults: The Sydney Memory and Ageing Study.

The American Journal of Geriatric Psychiatry.

2016, Mar; 24(3): 221-31

Ibrahim-Verbaas, C.,… et al.

GWAS for executive function and processing speed suggests involvement of the CADM2 gene. 

Molecular Psychiatry. 2016, Feb; 21(2):189-97

Tuerk C, Zhang H, Sachdev P, Lord SR, Broday H, Wen W, Delbaere K.

Regional Grey Matter Volumes Are Related To Concern About Falling In Older People: A Voxel-Based Morphometric Study.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2016, Jan; 71(1):138-44.

Yang ZWen WJiang JCrawford JDReppermund SLevitan CSlavin MJKochan NARichmond RLBrodaty HTrollor JNSachdev PS.

Structural MRI biomarkers of mild cognitive impairment from young elders to centenarians.

Current Alzheimer Research. 2016, 13(3):256-67

Zhang HSachdev PSWen WCrawford JDBrodaty HBaune BTKochan NASlavin MJReppermund SKang KTrollor JN.

The relationship between inflammatory markers and voxel-based grey matter volumes in non-demented older adults.

Neurobiology of Aging. 2016, Jan; 37: 138-46

2015

Boraxbekk CJ, Ames D, Kochan NA, Lee T, Thalamuthu A, Wen W, Armstrong NJ, Kwok JB, Schofield PR, Reppermund S, Wright MJ, Trollor JN, Brodaty H, Sachdev P, Mather KA.

Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals.

Neuropsychologia. 2015, Sep 28;78:10-17

Connors MH, Sachdev PS, Kochan N, Xu J, Draper B, Brodaty H.

Cognition and Mortality in Older People: The Sydney Memory and Ageing Study.

Age Ageing. 2015, 44 (6): 1049-1054

Jayasena T, Poljak A, Braidy N, Smythe G, Raftery M, Hill M, Brodaty H, Trollor J, Kochan NA, Sachdev PS.

Upregulation of Glycolytic Enzymes, Mitochondrial Dysfunction and Increased Cytotoxicity in Glial Cells Treated with Alzheimer’s Disease Plasma.

PLOS ONE. 2015, Mar 18;10(3):e0116092

Perry A, Wen W, Lord A, Thalamuthu A, Roberts G, Mitchell PB,  Sachdev PS, Breakspear M.

The organisation of the elderly connectome.

NeuroImage. 2015, Volume 114, Pages 414-426, ISSN 1053-8119

Jiang J, Wen W, Brown D, Crawford J, Thalamuthu A, Smith E, Breit S, Liu T, Zhu W, Brodaty,H, Baune B, Trollor J and Sachdev P. 

The relationship of serum Macrophage Inhibitory Cytokine - 1 levels with gray matter volumes in community-dwelling older individuals.

PLOS ONE. 2015,vol 10, no 4

Jiang J, Trollor J, Brown D, Crawford J, Thalamuthu A, Smith E, Breit S, Liu T, Brodaty H, Baune B, Sachdev P and Wen W.

An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity in community-dwelling older individuals.

Psychoneuroendocrinology. 2015,vol 62 , pp 80 - 88

Waggel S, Lipnicki DM, Delbaere K, Kochan NA, Draper B, Andrews G, Sachdev PS, Brodaty H.

Neuroticism scores increase with late-life cognitive decline.

International Journal of Geriatric Psychiatry. 2015. 30 (9): 985-993

Chan JPL, Thalamuthu A, Oldmeadow C, Armstrong NJ, Holliday EG, McEvoy M, Kwok JB, Assareh AA, Peel R, Hancock SJ, Reppermund S, Menant J, Trollor JN, Brodaty H, Schofield PR, Attia JR, Sachdev PS, Scott RJ, Mather KA.

Genetics of hand grip strength in mid to late life.

AGE. 2015,37(1), 9745

Mather KA, Armstrong N, Wen W, Kwok JB, Assareh A, Thalamuthu A, Reppermund S, Duesing K, Wright MJ, Ames D, Trollor JN, Brodaty H, Schofield PR, Sachdev PS.

Investigating the Genetics of Hippocampal Volume in Older Adults without dementia.

PLOS ONE. 2015, 10(1): e0116920 

Hibar DP,….., Mather KA. et al.

Common genetic variants influence human subcortical brain structure. 

Nature. 2015,9 (12), 224-9

Debette S.,…, Mather KA, et al.

Genome-wide studies of verbal declarative memory in non-demented older people: the CHARGE consortium.

Biological Psychiatry. 2015, 77 (8), 749-63

Poole SG, Bell JS, Jokanovic N, Kirkpatrick CM, Dooley MJ.

A systematic review of medication exposure assessment in prospective cohort studies of community dwelling older Australians.

PLOS ONE. 2015, 10(4): e0124247.

Samaras KCrawford JLutgers HLCampbell LVBaune BTLux OBrodaty HTrollor JNSachdev P.

Metabolic Burden and Disease and Mortality Risk Associated with Impaired Fasting Glucose in Elderly Adults.

Journal of the American Geriatrics Society. 2015 Jul;63(7):1435-42

Valenzuela M, Breakspear M, Sachdev P, Wen W, Kochan N.

Posterior compensatory network in cognitively intact elders with hippocampal atrophy.

Hippocampus. 2015, May; 25(5): 581-93

Davies G.,…., Mather KA, et al.

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE Consortium (N= 53 949).

Molecular Psychiatry. 2015, 20(2), 183-92

Lazarus J, Mather KA, Armstrong NJ, Song F, Poljak A, Thalamuthu A, Lee T, Kochan NA, Brodaty H, Wright MJ, Ames D, Sachdev PS, Kwok JB. 

DNA methylation in the apolipoprotein-A1 gene is associated with episodic memory performance in healthy older individuals.

Journal of Alzheimer’s Disease. 2015,44(1): 175-82 

Slavin MJ, Sachdev PS, Kochan NA, Woolf C, Crawford JD, Giskes K, Reppermund S, Trollor JN, Draper B, Delbaere K, Brodaty H.

Predicting cognitive, functional and diagnostic change over four years using baseline subjective cognitive complaints in the Sydney Memory and Ageing Study.

The American Journal of Geriatric Psychiatry. 2015. 23(9): 906–914

Kvelde T, Lord SR, Close JCT, Reppermund S, Kochan NA, Sachdev P, Brodaty H, Delbaere K.

Depressive symptoms increase fall risk in older people, independent of antidepressant use, and reduced executive and physical functioning.

Archives of Gerontology and Geriatrics. 2015, 60(1):190-195

2014

Authors

Title

Journal

Samaras K, Lutgers HL, Kochan NA, Crawford JD, Campbell LV, Wen W, Slavin MJ, Baune BT, Lipnicki D, Brodaty H, Trollor JN, Sachdev PS.

The impact of glucose disorders on cognition and brain volumes in the elderly: The Sydney Memory and Ageing Study.

Age. 2014, Apr; 36(2):977-93

Arcot J, Kim J, Trollor J, Brodaty H, Crawford J, Sachdev P.

Anthropometric indices in a community-dwelling Australian population aged 70-90 years: The Sydney Memory and Ageing Study.

Nutrition & Dietetics.

Published online: 11 SEP 2014

Smith E, Bailey PE, Crawford J, Samaras K, Baune BT, Campbell L, Menant J, Sturnieks DL, Brodaty H, Sachdev P, Trollor JN.

Adiposity estimated by dual energy x-ray absorptiometry and body mass index and its association with cognition in the elderly.

Journal of American Geriatric Society. 2014, Dec; 62(12): 2311-8

Callisaya ML, Srikanth VK, Lord SR, Close JT, Brodaty H, Sachdev PS, Phan T, Beare R, Trollor J, Wen W, Zheng JJ, Delbaere K.

Subcortical infarcts and the risk of falls in older people: Combined results of TASCOG and Sydney MAS studies.

International Journal of Stroke. 2014, Oct;9 Suppl A100:55-60

Reppermund S, Zhuang L, Wen W, Slavin MJ, Trollor JN, Brodaty H, Sachdev PS.

White Matter Integrity and Late-Life Depression in Community-Dwelling Individuals. A diffusion tensor imaging study using tract-based spatial statistics.

British Journal of Psychiatry. 2014 Oct;205(4):315-20

Seeher KM, Low LF, Reppermund S, Slavin MJ, Draper BM, Kang K, Kochan NA, Trollor JN, Sachdev PS, Brodaty H.

Correlates of psychological distress in study partners of older people with and without mild cognitive impairment (MCI) – the Sydney Memory and Ageing Study.

Aging & Mental Health. 2014, 18(6):694-705

Brodaty H, Mothakunnel A, de Vel-Palumbo M, Ames D, Ellis KA, Reppermund S, Kochan NA, Savage G, Trollor J, Crawford J, Sachdev PS

Influence of population versus convenience sampling on sample characteristics in studies of cognitive aging.

Annals of Epidemiology. 2014, Jan;24(1):63-71

Jiang J, Sachdev P, Lipnicki DM, Zhang H, Liu T, Zhu W, Suo C, Zhuang L, Crawford J, Reppermund S, Trollor J, Brodaty H, Wen W.

A longitudinal study of brain atrophy over two years in community-dwelling older individuals.

NeuroImage. 2014, Feb 1;86:203-11

Callisaya ML, Srikanth VK, Lord SR, Close JT, Brodaty H, Sachdev PS, Phan T, Beare R, Trollor J, Wen W, Zheng JJ, Delbaere K.

Subcortical infarcts and the risk of falls in older people: Combined results of TASCOG and Sydney MAS studies.

International Journal of Stroke. 2014, Oct;9 Suppl A100:55-60

Wong AKW, Lord SR, Trollor JN, Sturnieks DL, Delbaere K, Menant J, Brodaty H, Sachdev PS, Close JCT.

Increased Arterial Pulse Wave Velocity is a Risk Factor for Falls in Community-dwelling Older People.

Journal of the American Geriatric Society.  2014, Aug;62(8):1534-9

Ising M, Zimmerman P, Bruckl T, Hohne N, Heck A, Schenk LA, Rejuescu D, Armstrong NJ, Sachdev PS, Reppermund S.

Genetic effects on information processing speed are moderated by age – converging results from 3 samples. 

Genes, Brain and Behavior. 2014, Volume 13, Issue 5, pages 501–507

Raamana PR, Wen W, Kochan N, Brodaty H, Sachdev P, Wang L, Beg MF.

Novel ThickNet features for the discrimination of amnestic MCI subtypes.

NeuroImage Clinical. 2014, 6: 284-295

Song F, Poljak A, Kochan NA, Raftery M, Brodaty H, Smythe GA, Sachdev PS.

Plasma protein profiling of Mild Cognitive Impairment and Alzheimer's disease using iTRAQ quantitative proteomics.

Proteome Science.  2014 Jan 17; 12(1):5

Raamana P, Wen W, Kochan NA, Brodaty H, Sachdev PS, Wang L and Beg M.

The sub-classification of amnestic mild cognitive impairment using MRI-based cortical thickness measures.

Frontiers in Neurology. 2014, 5:76

 2013

Authors

Title

Journal

Fuchs T, Trollor J, Crawford J, Brown D, Baune B, Samaras K, Campbell L, Breit S, Brodaty H, Sachdev P and Smith E. 

Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline: the Sydney Memory and Aging Study.

Aging Cell. 2013,12(5): 882 - 889

Dobson-Stone C, Polly P, Korgaonkar MS, Williams LM, Gordon E, Schofield PR, Mather K.A., Armstrong NJ, Wen W, Sachdev PS, Kwok JB.

GSK3B and MAPT Polymorphisms Are Associated with Grey Matter and Intracranial Volume in Healthy Individuals. 

PLOS ONE. 2013, 12;8(8):e71750

Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Rockwood K, Xiao S, Li J, Li X, Brayne C, Matthews FE, Stephan BCM, Lipton RB,  Katz MJ, Ritchie K, Carrière I, Ancelin ML, Seshadri S, Au R, Beiser AS, Lam LCW, Wong CHY, Fung AWT, Kim KW, Han JW, Kim TH, Petersen RC, Roberts RO, Mielke MM, Ganguli M,  Dodge H, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Meguro K, Schupf N, Manly J, Stern Y,Lobo A, Lopez-Anton R, Santabárbara J, for COSMIC

COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.

BMC Neurology. 2013, 13:165

Zhang H, Sachdev PS, Wen W, Kochan NA, Crawford JD, Brodaty H, Slavin MJ, Reppermund S, Kang K, TrollorJN

Grey Matter Correlates of Three Language Tests in Non-demented Older Adults.

PLOS ONE. 2013 Nov 5;8(11):e80215

Fuchs T, Trollor JN, Crawford J, Brown D, Baune BT, Samaras K, Campbell L, Breit SN, Brodaty H,  Sachdev P, Smith E

Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline – the Sydney Memory and Ageing Study.

Aging Cell 2013 Oct;12(5):882-9

Liu T, Sachdev PS, Lipnicki DM, Jiang J, Geng G, Zhu W, Reppermund S, Tao D, Trollor JN, Brodaty H, Wen W

Limited relationships between two-year changes in sulcal morphology and other common neuroimaging indices in the elderly.

NeuroImage 2013 Dec;83:12-7

Reppermund S, Brodaty H, Crawford JD, Kochan NA, Draper B, Slavin MJ, Trollor JN, Sachdev PS

Impairment in Instrumental Activities of Daily Living with High Cognitive Demand is an Early Marker of Mild Cognitive Impairment: The Sydney Memory and Ageing Study.

Psychological Medicine 2013 Nov;43(11):2437-45

 

 

Tsang RSM, Sachdev PS, Reppermund S, Kochan NA, Kang K, Crawford J, Wen W, Draper B, Trollor JN, Slavin MJ, Mather KA, Assareh A, Seeher KM, Brodaty H

Sydney Memory and Ageing Study: An epidemiological cohort study of brain ageing and dementia.

International Review of Psychiatry. 2013, 25(6), 711-725.

Brodaty H, Heffernan M, Kochan NA, Draper B, Trollor JN, Reppermund S, Slavin MJ, Sachdev PS

Mild Cognitive Impairment in a community sample: The Sydney Memory and Ageing Study.

Alzheimers Dement. 2013, May;9(3):310-317

Lipnicki DM, Sachdev PS, Crawford J, Reppermund S, Kochan NA, Trollor JN, Draper B, Slavin MJ, Kang K, Lux O, Mather KA, Brodaty H, and the Sydney Memory and Ageing Study Team

Risk factors for late-life cognitive decline and variation with age and sex in the Sydney Memory and Ageing Study.

PLOS ONE. 2013, 8(6): e65841

Liu T, Sachdev PS; Lipnicki DM; Jiang J; Cui Y; Kochan NA; Reppermund S; Trollor JN; Brodaty H, Wen W

Longitudinal changes in sulcal morphology associated with late-life aging and MCI.

NeuroImage. 2013; 74: 337-342

Menant JC, Wong A, Sturnieks DL, Close JCT, Delbaere K, Sachdev PS, Brodaty H, Lord SR

Pain and anxiety mediate the relationship between dizziness and falls in older people.

Journal of the American Geriatric Society. 2013, Mar;61(3):423-8

Sachdev PS, Lipnicki DM, Crawford J, Reppermund S, Kochan NA, Trollor JN, Wen W, Draper B, Slavin MJ, Kang K, Lux O, Mather KA, Brodaty H

Factors predicting reversion from mild cognitive impairment to normal cognitive functioning: a population-based study.

PLOS ONE. 2013,8(3):e59649

Schilling S. , DeStefano, A.L.,  Sachdev, P.S. Choi, S.H., Mather, K.A., DeCarli, C.D., Wen, W., Hogh, P., Raz, N., Au, R., Beiser, A.S., Wolf, P.A., Romero, J.R., Zhu, Y-C., Lunetta, K.L., Farrer, L.A., Dufouil, C., Kuller, L.H.,  Mzoyer, B., Seshadri, S., Tzourio, C., Debette, S.

APOE genotype and MRI-markers of cerebrovascular disease:

A systematic review and meta-analysis.

Neurology. 2013, Jul 16;81(3):292-300

Singer J, Trollor JN, Crawford J, O'Rourke MF, Baune BT, Brodaty H, Samaras K, Kochan NA, Campbell L, Sachdev PS, Smith E.

The Association between Pulse Wave Velocity and Cognitive Function: The Sydney Memory and Ageing Study.

PLOS ONE. 2013, Apr 30;8(4):e61855

Shahnawaz Z, Reppermund S, Brodaty H, Crawford JD, Draper B, Trollor JN, Sachdev PS

Prevalence and Characteristics of Depression in Mild Cognitive Impairment: The Sydney Memory and Ageing Study.

Acta Psychiatrica Scandinavica. 2013; 127:394-402

Sturnieks DL, Menant J, Delbaere K, Vanrenterghem J, Rogers MW, Fitzpatrick R, Lord SR

Force-controlled balance perturbations associated with falls in older people.

PLOS ONE. 2013, 8(8): e70981

Valenzuela MJ, Leon I, Suo C, Piamba DM, Kochan N, Brodaty H, Sachdev P. 

Cognitive lifestyle in older persons: the population-based Sydney Memory and Ageing Study.

Journal of Alzheimer’s Disease J Alzheimers Dis. 2013, Jan 1;36(1):87-97.

Wong A, Lord SR, Sturnieks DL, Delbaere K, Trollor JN, Close JCT

Angiotensin System Blocking Medications are Associated with Fewer Falls over 12 Months in Community Dwelling Older People.

J Am Geriatr Soc. 2013, May;61(5):776-81

Zhuang L, Sachdev PS, Trollor JN, Reppermund S, Kochan NA, Brodaty H, Wen W

Microstructural white matter changes, not hippocampal atrophy, detect early amnestic mild cognitive impairment.

PLOS ONE. 2013; 8(3):e58887

2012

Authors

Title

Journal

Baune BT, Smith E, Reppermund S, Air T, Samaras K, Lux O, Brodaty H, Sachdev P, Trollor JN

Inflammatory biomarkers predict Depression, but not Anxiety during Aging: The Prospective Sydney Memory and Aging Study.

Psychoneuroendocrinology. 2012, Sep;37(9):1521-30.

Brodaty H, Heffernan M, Kochan NA, Draper B, Trollor JN, Reppermund S, Slavin MJ, Sachdev PS

Neuropsychiatric symptoms in older people with and without cognitive impairment.

Journal of Alzheimer’s Disease. 2012, 31: 411–420

Cui Y, Sachdev PS, Lipnicki DM, Jin JS, Luo S, Zhu W, Kochan NA, Reppermund S, Liu T, Trollor JN, Brodaty H, Wen W

Predicting the development of mild cognitive impairment: A new use of pattern recognition.

Neuroimage. 2012, Jan 25;60(2):894-901

Cui Y, Wen W, Lipnicki DM, Beg MF, Jin JS, Luo S, Zhu W, Kochan NA, Reppermund S, Zhuang L, Ramana PR, Liu T, Trollor JN, Wang L, Brodaty H, Sachdev PS

Automated detection of amnestic mild cognitive impairment in community-dwelling elderly adults: a combined spatial atrophy and white matter alteration approach

Neuroimage. 2012, Jan 16;59(2):1209-17

Delbaere K, Kochan NA, Close JC, Menant JC, Sturnieks DL, Brodaty H, Sachdev PS, Lord SR

Mild cognitive impairment as a predictor of falls in community-dwelling older people.

Am J Geriatr Psychiatry. 2012, Oct;20(10):845-853

Delbaere K, Close JC,  Kochan NA, Sachdev PS, Lord SR

Good memory as a predictor of falls: FACT or artefact.

Age Ageing. 2012, 41(3):404-8.

Haerer W, Delbaere K, Lord SR, Rowland, J

Relationships Between Hmg-Coa Reductase Inhibitors (Statin) Use and Strength, Balance and Falls in Older People.

Internal Medicine Journal. 2012, Dec;42(12):1329-34.

Henry JD, Thompson C, Rendel PG, Phillips LH, Carbert J, Sachdev P, Brodaty H

Perception of biological motion and emotion in mild cognitive impairment and dementia.

Journal of the International Neuropsychological Society. 2012, Sep;18(5):866-73

Low L-F, Harrison F, Kochan NA, Draper B, Slavin MJ, Reppermund S, Sachdev PS, Brodaty H

Can Mild Cognitive Impairment be accurately diagnosed in English speakers from linguistic minorities? Results from the Sydney Memory and Ageing Study.

Am J Geriatr Psychiatry. 2012, Oct;20(10):866-77

Menant JC, Close JC, Delbaere K, Sturnieks DL, Trollor J, Sachdev PS, Brodaty H, Lord SR

Relationships between serum vitamin D levels, neuromuscular and neuropsychological function and falls in older men and women.

Osteoporos Int. 2012, Mar;23(3):981-9

Sachdev PS, Lipnicki DM, Crawford J, Reppermund S, Kochan NA, Trollor JN, Draper B, Slavin MJ, Kang K, Lux O, Mather KA, Brodaty H, and the Sydney Memory and Ageing Study Team

Risk profiles for mild cognitive impairment vary by age and sex: The Sydney Memory and Ageing Study.

Am J Geriatr Psychiatry. 2012, Oct;20(10):854-865

Sachdev PS, Lipnicki DM, Crawford J, Reppermund S, Kochan NA, Trollor JN, Draper B, Slavin MJ, Kang K, Lux O, Mather KA, Brodaty H and the Memory and Ageing Study Team

Risk profiles of subtypes of mild cognitive impairment: The Sydney Memory and Ageing Study.

J Am Geriatr Soc. 2012, Jan;60(1):24-33

Samaras K, Trollor J, Sachdev P, Brodaty H, Smith E, Campbell L, Baune B,  Lux O, Crawford J

The Value of the Metabolic Syndrome Concept in Elderly Adults: Is It Worth Less Than the Sum of Its Parts?

J Am Geriatr Soc. 2012, Sep;60(9):1734-41

Song F, Poljak A, Crawford J, Kochan NA, Wen W , Cameron B, Lux O, Brodaty H, Mather K, Smythe GA,  Sachdev PS

Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals.

PLOS ONE. 2012, 7(6):e3407

Sturnieks D, Menant J, Vanrenterghem J, Delbaere K, Fitzpatrick RC, Lord S

Sensorimotor and Neuropsychological Correlates of Force Perturbations that Induce Stepping in Older Adults.

Gait and Posture. 2012, 36(3):356-60

Suo C, Leon I, Brodaty H, Trollor J, Wen W, Sachdev P, Valenzuela M

Supervisory Experience at Work is Linked to Low Rate of Hippocampal Atrophy in Late Life.

Neuroimage. 2012, Aug 12;63(3):1542-1551

Thillainadesan S, Wen W, Zhuang L, Crawford J, Kochan N, Reppermund S, Slavin M, Trollor J, Brodaty H, Sachdev P

Changes in Mild Cognitive Impairment and its subtypes as seen on Diffusion Tensor Imaging.

International Psychogeriatrics. 2012, 24(9):1483-1493

Trollor JN, Smith E, Agars E, Kuan SA, Baune BT, Campbell L, Samaras K, Crawford J, Lux O, Kochan NA, Brodaty H, Sachdev P.

The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study.

Age (Dordr). 2012, Oct;34(5):1295-308.

Zhang H, Trollor JN, Wen W, Kochan NA, Crawford JD, Brodaty H, Slavin MJ, Reppermund S, Draper B, Zhu W, Kang K, Sachdev PS

Gray Matter Atrophy Patterns of Mild Cognitive Impairment Subtypes.

Journal of the Neurological Sciences. 2012, 315: 26–32

Zheng JJ, Delbaere K, Close JC, Sachdev PS, Wen W, Brodaty H, Lord SR

White Matter Hyperintensities Are an Independent Predictor of Physical Decline in Community-Dwelling Older People.

Gerontology. 2012;58(5):398-406

Zheng JJ, Lord SR, Close JC, Sachdev PS, Wen W, Brodaty H, Delbaere K

Brain white matter hyperintensities, executive dysfunction, instability and falls in older people: a prospective cohort study.

J Gerontol A Biol Sci Med Sci. 2012, Oct;67(10):1085-91

Zheng JJ, Delbaere K, Close JCT, Sachdev PS, Wen W, Lord SR

White matter hyperintensities and impaired choice stepping reaction time in older people.

Neurobiol Aging. 2012, 33(7):1177-85

Zhuang L, Sachdev P, Trollor J, Kochan N, Reppermund S, Brodaty H, Wen W.

Microstructural white matter changes in cognitively normal individuals at risk of amnestic MCI.

Neurology. 2012, Aug 21;79(8):748-54

Zhuang L, Wen W, Trollor JN, Kochan NA, Reppermund S, Brodaty H, Sachdev PS

Abnormalities of the fornix in Mild Cognitive Impairment are related to episodic memory loss.

Journal of Alzheimer’s Disease. 2012, 28, 1-11

2011

Authors

Title

Journal

Delbaere K, Smith S, Lord S.

Development and Initial Validation of the Iconographical Falls Efficacy Scale.

J Gerontol A Biol Sci Med Sci. 2011, 66A:674-680

Liu T, Wen W, Zhu W, Kochan NA, Trollor JN, Reppermund S, Jin JS, Luo S, Brodaty H, Sachdev PS

The relationship between cortical sulcal variability and cognitive performance in the elderly.

Neuroimage. 2011, 56, 865-873

Kochan NA, Breakspear M, Valenzuela M, Slavin MJ, Brodaty H, Wen W, Trollor JN, Turner A, Crawford JD, Sachdev PS

Cortical Responses to a Graded Working Memory Challenge Predict Functional Decline in Mild Cognitive Impairment.

Biological Psychiatry. 2011, 70(2):123-30

Reppermund S, Brodaty H, Crawford JD, Kochan NA, Slavin MJ, Trollor JN, Draper B, Sachdev PS

The relationship of current depressive symptoms and past depression with cognitive impairment and instrumental activities of daily living in an elderly population:  the Sydney Memory and Ageing Study.

Journal of Psychiatric Research, 2011, 45(12):1600-7

Reppermund S, Sachdev PS, Crawford J, Kochan NA, Slavin MJ, Kang K, Trollor JN, Draper B, Brodaty H.

The relationship of neuropsychological function to instrumental activities of daily living in mild cognitive impairment.

Int J Geriatr Psychiatry. 2011, 26(8):843-52

Wen W, Zhu W, He Y, Kochan NA, Reppermund S, Slavin MJ, Brodaty H, Crawford J, Xia A, Sachdev P

Discrete Neuroanatomical Networks Are Associated with Specific Cognitive Abilities in Old Age.

J Neurosci. 2011, 31(4):1204-1212

Zhang H, Trollor JN, Wen W, Zhu W, Crawford JD, Kochan NA, Slavin MJ, Brodaty H, Reppermund S, Kang K, Mather KA, Sachdev PS

Gray matter atrophy of basal forebrain and hippocampus in mild cognitive impairment.

J Neurol Neurosurg Psychiatry. 2011, May;82(5):487-93

Zhang H, Sachdev PS, Wen W, Kochan NA, Zhu W, Crawford JD, Brodaty H, Slavin MJ, Reppermund S, Kang K, Trollor JN

Neuroanatomical correlates of cognitive performance in late life.

Dement Geriatr Cogn Disord. 2011, 32:216-226

Zheng JJ, Delbaere K, Close JC, Sachdev PS, Lord SR.

Impact of white matter lesions on physical functioning and fall risk in older people: a systematic review.

Stroke. 2011, Jul;42(7):2086-90

Authors

Title

Journal

Delbaere K, Hauer K, Lord SR

Evaluation of the incidental and planned exercise questionnaire (IPEQ) for older people.

British Journal of Sports Medicine. 2010, 44(14):1029-34

Delbaere K, Close JC, Heim J, Sachdev PS, Brodaty H, Slavin MJ, Kochan NA, Lord SR

A multifactorial approach to understanding fall risk in older people.

J Am Geriatr Soc. 2010, 58 (9):1679-85.

Delbaere K, Close JC, Brodaty H, Sachdev P, Lord SR

Determinants of disparities between perceived and physiological risk of falling among elderly people: cohort study.

BMJ. 2010, Aug 18;341:c4165

Delbaere K, Close JC, Mikolaizak AS, Sachdev PS, Brodaty H, Lord SR

The Falls Efficacy Scale International (FES-I). A comprehensive longitudinal validation study.

Age Ageing. 2010 Mar; 39(2):210-6

Kochan NA, Slavin MJ, Brodaty H, Crawford JD, Trollor JN, Draper B, Sachdev PS

Effect of Different Impairment Criteria on Prevalence of ‘Objective’ Mild Cognitive Impairment in a Community Sample.

AJGP. 2010, 18: 711-722

Kochan NA, Breakspear M, Slavin MJ, Valenzuela M, McCraw S, Brodaty H, Sachdev PS

Functional alterations in brain activation and deactivation in mild cognitive impairment in response to a graded working memory challenge.

Dement Geriatr Cogn Disord. 2010, 30(6):553-68

Liu T, Wen W, Zhu W, Trollor J, Reppermund S, Crawford J, Jin JS, Luo S, Brodaty H, Sachdev P

The effects of age and sex on cortical sulci in the elderly.

Neuroimage 2010, 51(1):19-27

Sachdev PS, Brodaty H, Reppermund S, Kochan NA, Trollor JN, Draper B, Slavin MJ, Crawford J, Kang K, Broe GA, Mather KA, Lux O; Memory and Ageing Study Team

The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years.

Int Psychogeriatr. 2010, 22(8):1248-64

Slavin MJ, Brodaty H, Kochan NA, Crawford JD, Trollor JN, Draper B, Sachdev PS

Prevalence and Predictors of 'Subjective Cognitive Complaints' in the Sydney Memory and Ageing Study.

AJGP. 2010, 18: 701-710

Trollor JN, Smith E, Baune BT, Kochan NA, Campbell L, Samaras K, Crawford J, Brodaty H, Sachdev P.

Systemic Inflammation Is Associated with MCI and Its Subtypes: The Sydney Memory and Aging Study.

Dement Geriatr Cogn Disord. 2010, 30(6):569-78

Zhuang L, Wen W, Zhu W, Trollor J, Kochan N, Crawford J, Reppermund S, Brodaty H, Sachdev P.

White matter integrity in mild cognitive impairment: a tract-based spatial statistics study.

Neuroimage. 2010, Oct 15;53(1):16-25

2009

Authors

Title

Journal

Chua TC, Wen W, Chen X, Kochan N, Slavin MJ, Trollor JN, Brodaty H, Sachdev PS

Diffusion tensor imaging of the posterior cingulate is a useful biomarker of mild cognitive impairment.

Am J Geriatr Psychiatry. 2009, 17(7):602-13

Delbaere K, Sturnieks DL, Crombez G, Lord SR

Concern About Falls Elicits Changes in Gait Parameters in Conditions of Postural Threat in Older People.

J Gerontol A Biol Sci Med Sci. 2009, 64, No. 2, 237–242

 

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