The International Centenarian Consortium of Dementia (ICC-Dementia) aims to explore factors that predict successful ageing into the 11th decade of life that are robust across international cohorts through international collaboration and data sharing. This project is motivated by the variation in approaches for diagnosing dementia and cognitive impairment across studies and the under-studied questions including the global prevalence of dementia in persons aged 95 and above and the risk and protective factors for dementia across ethno-regional groups of long-lived individuals.
- Define global dementia prevalence in centenarians and near-centenarians (95+) using uniform diagnostic criteria.
- Identify and examine risk and protective factors for dementia, cognitive and functional impairments, and determine whether their effects vary between centenarian studies.
- Develop and apply a protocol to harmonise neuropsychological data collected by 17 centenarian studies from around the world.
- Calculate the prevalence rates of dementia, cognitive and functional impairments using standard diagnostic criteria that were commonly applied in the literature.
- Examine the associations of age, sex, education and residential status on the prevalence rates of dementia and impairments.
- Conduct independent participant data (IPD) meta-analysis to examine the heterogeneity of the associations of these risk (and protective) factors on dementia prevalence across international studies.
- Project leaders: Scientia Professor Perminder Sachdev and Scientia Professor Henry Brodaty
- Coordinator: Dr Yvonne Leung
- Co-investigators: Dr Nicole Kochan and Dr John Crawford
- International members of ICC-Dementia
This project is governed under the ICC-Dementia consortia led by CHeBA.