Proteomics is the large scale study of the protein complement of a living organism. Proteins are involved in a range of cellular processes, including ageing. We hope to better understand this role by studying protein expression, function and changes in normal ageing and age-related disorders, such as Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD).
We have plasma samples from several population-based longitudinal studies. Both cross-sectional and longitudinal data are used to identify robust markers which are replicated in independent studies, to explore the effects of genetics vs life-style factors and factors associated with super-longevity. Psychometric, brain volumetric and genetic data are available for comparison with proteomics output and together these techniques are helping us to discover new proteins and pathways associated with disease onset and progression.