Amyloid PET in the Older Australian Twins Study

image - PiB PET In Twins Study%281%29
Project Members: 
image - Assoc Prof Wei Wen
Associate Professor
Ph +61 2 9382 3730 or +61 2 9385 0438
image - RK 4
Conjoint Associate Lecturer
Project Main Description: 

A hallmark feature of Alzheimer’s disease (AD) is a build up of amyloid plaques in the brain, which typically starts many years before symptoms are observed. We used amyloid PET brain scans to investigate this plaque build-up in pairs of twins at risk of developing AD. The data is currently undergoing analysis to calculate the heritability of these plaques - that is, to determine to what degree genes play a role. We are also investigating potentially modifiable environmental factors that may be contributing to the relationship between plaques and memory and thinking.

Amyloid PET in the Older Australian Twins Study - PET Brain Scan


Project Members:

Professor Perminder Sachdev, Project Lead, CHeBA
Professor Christopher Rowe, Nuclear Medicine Specialist, Department of Nuclear Medicine, Centre for PET, University of Melbourne, Austin Health
Associate Professor Wei Wen, Head of the Neuroimaging Laboratory, CHeBA
Dr Anbupalam Thalamuthu, Biostatistician, CHeBA
Dr Rebecca Koncz, PhD Candidate, CHeBA

In conjuction with the Older Australian Twins Study team.

Project Supporters: 

The pilot study was funded by the NHMRC.  This study received further funding through an NHMRC project grant for 2015-2017.

Project Status: 
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