image - MiRNA Cloud
Tags: miRNA, microRNA, Blood biomarkers, Alzheimer's Disease, dementia, diagnosis Status: Current

One of the barriers to the development of effective therapy for Alzheimer's disease (AD) is the lack of a specific biomarker that allows identification of the disease prior to the onset of clinically apparent cognitive impairment when the underlying brain pathology is already advanced and damage...

image - Proteomics Compressed
Tags: Proteomics, Alzheimer's Disease, Apolipoproteins Status: Current

Blood is not only a repository for a variety of disease biomarkers, but its constituents can also reflect the status of the body as it ages, responds to lifestyle and environmental impacts such as nutrition, exercise and education, and reflects changes within the body such as response to disease...

image - Jaemin
Status: Current

Proteomics is the large scale study of the protein complement of a living organism. Proteins are involved in a range of cellular processes, including ageing. We hope to better understand this role by studying protein expression, function and changes in normal ageing and age-related disorders,...

image - Sto
Status: Current

Prior investigations of human brain structural networks have primarily focused on healthy young adults and clinical samples. We study the scans of community-dwelling participants aged 70-90 years in order to examine normal age-related changes in the structural organisation of the elderly brain...

image - Neuroinflammation 0
Status: Current

Using circulating inflammatory markers and magnetic resonance imaging (MRI), recent studies have associated inflammation with brain volumetric measures. We investigate the relationship between a novel inflammatory biomarker and grey matter volumes in the brain, which may help in the early...

Status: Current

Diagnosis of mild dementia and Mild Cognitive Impairment (MCI) is challenging because cognitive problems are subtle and difficult to detect. Therefore, diagnosis is commonly delayed and many older adults will not receive a diagnosis at all. Our study will evaluate the potential of a brief,...

Picture of hands
Status: Current

The relationship between inflammation and geriatric depression is well-established, and offers the potential for the development of novel therapeutic strategies based on inflammatory targets. However, the relationship between depression and inflammation is complicated by age-associated factors (...

image - OATAS3
Tags: OATS; twins; twin study Status: Current

The Older Australian Twins Study is a longitudinal, multi-centre study that investigates healthy brain ageing in older twins (65+ years). Healthy ageing is characterised by low levels of disability, high cognitive and functional capacity, and an active engagement in life. The most important...

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