Principal Investigator
Professor Michael O’Sullivan
UQ Centre for Clinical Research
Building 71/918, Royal Brisbane Hospital Campus
Herston, 4029, QLD, Australia
Summary
| Country | UK |
|---|---|
| Principal Investigator | Michael O'Sullivan |
| Key publication/reference | |
| Years in which study conducted | 2013-2019 |
| Sample | |
| Size | 179 |
| Population: Hospital/community | Hospital |
| Selection: | Consecutive/random |
| Admit with previous stroke? | No |
| Admit with TIA? | No |
| Age range | 50-90 |
| Number of centres | 5 recruitment sites |
| Control group: number, population, selection | 32, local volunteers contacted via ageing research database |
| Assessment | |
| Initial assessment | On admission. Verification of inclusion and exclusion criteria, verification of capacity to consent, written informed consent |
| First detailed assessment | Approx. 30 days: History, including cardiovascular risk factors. IQCODE, MoCA, NART-R, free and cued selective reminding task (FCSRT), trails, digit symbol substitution task, digit span. Blood samples taken for biobank. |
| Follow-ups | 30-90 days, subset of eligible and consenting participants: MRI, paired associate learning (PAL; with and without interference), face recognition, process dissociation procedure (PDP), geriatric depression scale, letter and category fluency, Pyramids & Palm Trees, Door & People, Autobiographical Memory Interview, Corsi, serial reaction time, Stroop, Iowa gambling task. Approx. one year: MoCA, FCSRT, digit span. Participants in in-depth study only: PAL, PDP |
| Stroke-related data | Date of onset. Hemisphere. Size. Arterial territory |
| Functional tests/data | None |
| Other medical tests/data | Height, weight, blood pressure |
| Neuropsychological tests | |
| MRI scans, when and how many | One session at 30-90 days: High resolution T1 MPRAGE T2 FSE and FLAIR DWI (60 directions, 2 mm cubic voxels) Resting fMRI (6 min) 2 x ASL with TI of 1525 and 2525 msec Time of flight & SWAN |
| PET scans | Yes subset of 6 patients and 5 controls |
| Psychiatric exams | History of major psychiatric illness was an exclusion criterion |
| Dementia diagnosis criteria | Based on medical notes |
| Intervention trialled? | No |
