Principal Investigators
Contact: Behnam Sabayan
Clinical Neuroscience-Cerebrovascular Changes in Ageing and Dementia
Northwestern University
behnam.sabayan@northwestern.edu
Summary
| Countries | Scotland, Ireland, Netherlands |
|---|---|
| Principal Investigator | PROSPER study group |
| Contact person (email) | behnam.sabayan@northwestern.edul |
| Key publication/reference | Shepherd et al. Lancet (2002) |
| Years in which study conducted | 1997-2001 |
| Sample | |
| Size | 5804 (649 with history of stroke/TIA) |
| Population: Hospital/community | |
| Selection: consecutive/random | Selected based on a history of, or risk factors for, vascular disease |
| Admit with previous stroke or TIA | Yes: n=649 (321 placebo, 328 Pravastatin) |
| Admit with TIA? | Yes |
| Age range | 70–82 years |
| Number of centres | 3 |
| Control group: number, population, selection | Yes: Randomised controlled trial |
| Assessment | |
| Initial: Time and data collected/tests administered | Baseline, 9m, 18m, 30m, end of study |
| Detailed | |
| Subsequent (follow-ups) | Up to 3.2 y (mean) |
| Stroke-related data | --- |
| Functional tests/data | ADLs and IADLs |
| Other medical tests/data | CV risk factors, blood analysis, genotyping, medication and metabolic data |
| Neuropsychological tests | MMSE and test battery |
| MRI scans, when and how many | Baseline and at the end of trial (n=553) |
| PET scans | No |
| Psychiatric exams/diagnoses | GDS (subset) |
| Intervention trialled? | Pravastatin |
CT=computed tomography scan, MedHx=medical history, VRF=vascular risk factors (hypertension, diabetes, atrial fibrillation, obesity, smoking etc.), NΨ=neuropsychological, TIA=transient ischemic attack, m=month, y=year
