Metabolic and inflammatory factors have recently been proposed as key risk factors in cognitive ageing and age-related brain disorders such as the dementias. We are aiming to evaluate the influence of these factors on brain ageing and the modulating effects of genetic susceptibility, physical health, lifestyle and nutrition.
Our data derives from two large cohorts: the Older Australian Twins Study and the Memory and Ageing Study and is funded by the NHMRC.
The key objectives of the study include:
Our research enables us to evaluate these objectives in cross section and over a 2 year follow-up in both cohorts, thus providing us with data on the relevance of any identified biomarkers and their interactive effect on outcome. In addition, we will be able to determine an 'at risk' profile for elderly individuals for accelerated ageing effects. Identification of this profile is important as it will allow the development of interventions which may prevent or delay the onset of cognitive decline in late life.
Dr Anusha Ramchurn
Dr Czira Maria Eszter
Dr Helen Lutgers
Danielle Gregory, University of Adelaide PhD
Dr Alfred Wong, University of New South Wales, MD
Sharon Ong, University of New South Wales, MRes
Joel Singer, University of New South Wales, ILP
Su-Yin Yeong, University of New South Wales, ILP