Post-Stroke Dementia

CHeBA Visiting Lecture Series presents Professor Rajesh Kalaria of Newcastle University, for his talk:

Post-Stroke Dementia

The presentation will be followed by a live Q&A session with Professor Kalaria.

Dementia develops in 30% of elderly people who survive after stroke. Various brain structure changes associated with neurodegenerative dementias such as total cerebral volume, medial temporal lobe atrophy and cortical thinning, also relate to cognitive dysfunction in cerebrovascular disease. I will provide selected updates on the clinicopathological aspects of the primarily MRC funded Cognitive Function after Stroke (CogFAST) study, which began some 20 years ago. In this study, we demonstrate the association of coronary artery stenosis with stroke injury and suggest that coronary artery disease also enhances SVD type of pathology contributing to development of dementia in post-stroke survivors.

The work is supported by the Medical Research Council (UK), the Dunhill Medical Trust (UK), the Royal Society, Alzheimer’s Research UK (ARUK) and Alzheimer’s Society (AS), UK.


Raj Kalaria is Leader of Neurovascular Research Group in the Translational and Clinical Research Institute, Newcastle University.  He is a Professor of Pathology (Cerebrovascular Diseases) and a neuroepidemiologist.  He qualified from King’s College, University of London and the Royal College of Pathologists. His interests include the interface between Alzheimer disease (AD) and vascular dementia (VaD), Post-Stroke Dementia and Small Vessel Diseases of the Brain. He has contributed to consensus criteria for Vascular Cognitive Impairment and leads dementia research projects in indigenous populations of developing countries, particularly sub-Saharan Africa. Prof Kalaria is a member of the Africa Task Force of the European Academy of Neurology.  He is currently the liaison officer for IBRO-WFN and Chair/President of the International Society for Vascular Behavioural and Cognitive Disorders (VasCog).    

For more upcoming Visiting Lecture Series events as well as past presentations, CLICK HERE.

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