STROKOG Projects

STROKOG is a consortium of longitudinal studies of cognitive disorders following stroke, TIA or small vessel disease. Developed under the auspices of VASCOG (Society for the Study of Vascular Cognitive and Behavioural Disorders), it is the first international effort to harmonise work on post-stroke dementia.

Ongoing projects

1. Profile of post-stroke cognitive impairment in diverse geographical and ethno-cultural settings

Investigators: CHeBA team (Jess Lo, John Crawford, Nicole Kochan, Perminder Sachdev)

Contributing studies: Bundang-VCI (Korea), CASPER (the Netherlands), CogFAST-Nigeria (Nigeria), COAST (Singapore), Epi USA (USA), GRECOG-VASC (France), K-VCIHS (Korea), NEMESIS (Australia), NNI (Singapore), PROPSER (Ireland, Scotland, Netherlands), SAM (Finland), SSS (Australia), STROKDEM (France).

Aim: To examine the cognitive profile and impairment rates at 1-6 months post-stroke/TIA across geographical regions and to examine the association of risk factors have on cognition.

Methods: We harmonised data from 13 studies from Asia, Africa, Australia, Europe and USA. Neuropyschological test scores and appropriate normative data were used to calculate standardised cognitive domain scores, with percentile cut-offs from normative groups used to define impairment. One-stage IPD meta-analysis was used to examine the association between cognitive domain scores and potential risk factors (including hypertension, diabetes and AF).

Status: Analyses completed. Paper to be submitted in 2018.

2. External Validation of Dementia Risk Models in Stroke-Survivors (student project)

Investigators: Eugene Tang (Newcastle University, UK), Blossom Stephan (Newcastle University, UK)

Sponsors: Seb Koehler (CASPER), Louise Allan (CogFAST UK)

Aim: To use the STROKOG data resource to externally validate currently published dementia risk prediction models; and if model validation is found to be poor, develop new models for predicting risk of dementia in persons with stroke.

Status: Approved in June 2017. Currently in progress.

3. External Validation of risk scores for cognitive impairment five years after stroke (student project)

Investigators: Marion Fahey (King’s College London, UK), Abdel Douiri (King’s College London, UK)

Sponsor: Abdel Douiri (SLSR)

Aim: We have derived a patient specific tool which predicts cognitive impairment to a high level of accuracy (c-statistic: 0.70). However, the external validity of this model is unknown. The aim of this project is to use the STROKOG data resource to externally validate our cognitive decline model and if model validation is found to be poor, update the model to maximise external validity.

Status: Approved in September 2017. Currently in progress.

4. Stroke recovery associated with cognitive impairment: a population based study

Investigator: Clare Flach (King’s College London, UK)

Sponsor: Abdel Douiri (SLSR)

Title: Stroke recovery associated with cognitive impairment: a population based study.

Aim: To determine how cognitive impairment in the first three months after stroke is associated with physical, mental, social and care needs up to five years post-stroke.

Status: Approved in January 2018.

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