Sydney Stroke Study (SSS)

Principal Investigator

Perminder Sachdev
Neuropsychiatric Institute,
Prince of Wales Hospital,
Randwick NSW 2031, Australia.


Country Australia
Principal Investigator Perminder Sachdev
Contact person (email)
Key publication/reference Sachdev et al. Neurology 2004;62:912-919
Sachdev et al. J Neurol Neurosurg Psychiatry 2014
Years in which study conducted 1997-2005
Size 252
Population: Hospital/community Hospital
Selection: consecutive/random Consecutive
Admit with previous stroke? Yes
Admit with TIA? Yes
Age range 49-87
Number of centres 2
Control group: number, population, selection Healthy age-matched volunteers from the same neighbourhood as patients (n=129)
Initial: Time and data collected/tests administered Within 1 week: MedHx, function, VRF, MMSE
Detailed 3-6m: NΨ, psychiatric, MRI, IQCODE
Subsequent (follow-ups) 1y,3y,5y: NΨ
3y,5y: MRI
Stroke-related data European Stroke Scale
Functional tests/data SOFAS, ADL, IADL
Other medical tests/data APOE, MTHFR genotyping; blood analysis
Neuropsychological tests Test battery
MRI scans, when and how many 3-6m (67%),3y,5y: T1 and FLAIR
PET scans No
Psychiatric exams/diagnoses Dementia (DSM-IV), VaD, VCI, Depression (GDS, Hamilton)
Intervention trialled? No

CT=computed tomography scan, MedHx=medical history, VRF=vascular risk factors (hypertension, diabetes, atrial fibrillation, obesity, smoking etc.), NΨ=neuropsychological, TIA=transient ischemic attack, m=month, y=year

Further Details

For more details, see Sydney Stroke Study project.