St George's Cognition and Neuroimaging in Stroke (SCANS)

Principal Investigator

Professor Hugh Stephen Markus
University of Cambridge
Department of Clinical Neurosciences
Neurology Unit
Telephone number (+44) 01223 586661


Country UK
Principal Investigator Professor Hugh Stephen Markus
Contact person (email)
Key publication/reference Lawrence et al. PLoS One 2015: e0135523
Years in which study conducted Recruited 2007-10. Last follow-up 2015
Size 121
Population: Hospital/community Hospital
Selection: consecutive/random Consecutive SVD cases agreeing to participate
Admit with previous stroke? Yes
Admit with TIA? Yes but only if corresponding lacunar infarct
Age range 18+
Number of centres 1
Control group: number, population, selection Yes
Initial assessment At least 3 months post last stroke
First detailed assessment Baseline
Follow-ups Annually for 5 years
Stroke-related data Recurrent strokes
Functional tests/data GWAS on most
Other medical tests/data Cardiovascular risk factors
Neuropsychological tests Extensive screen
MRI scans, when and how many Annual MRI at baseline and years 1,2,3
PET scans No
Psychiatric exams GDS
Dementia diagnosis criteria Diagnostic and Statistical Manual of Mental Disorders V (DSM-V) (American Psychiatric Association, 2013) definition of "major neurocognitive disorder"
Intervention trialled? No