Leiden 85-plus study

Principal Investigator

Prof. dr Jacobijn Gussekloo
Master of Vitality and Ageing
Department of Internal Medicine, section of Gerontology and Geriatrics 
Department of Public Health and Primary Care 
Leiden University Medical Center, 
Leiden, the Netherlands 
Email: J.Gussekloo@lumc.nl

Data Contact

Dr Stella Trompet
Email: s.trompet@lumc.nl


Setting: Leiden, the Netherlands
Start Date: 1997
End Date: Cognitive function over 5 years till 2004, mortality till 2015 
Participants: 599 participants, all 85 years at baseline
Assessment Schedule: Annual interviews at home at age 85, 86, 87, 88, 89 and 90
Measures: (1) Neuropsychiatric and cognitive tests; (2) Clinical diagnosis of dementia; (3) Depression; (4) Broad range of sociodemographic data, lifestyle, functional status, QoL; (5) Health parameters: diseases, complaints, diagnosis, health care use; (6) Blood samples and genotyping; (7) Causes of death

Further Information

Bootsma-van der Wiel et al. A high response is not essential to prevent selection bias: Result from the Leiden 85-plus study. J Clin Epidemiol. 2002: 55;1119-1125.