Blog: The Brain Dialogues, filtered by tag: epigenetics

Research Officer in CHeBA’s Genetics & Epigenomics Group, Naga Mutyala, completed her PhD in March 2020 which focused on evaluating a rodent model and novel treatments for glioblastoma, a grade IV brain cancer, using gene expression profiling.  Glioblastoma is the most lethal grade of brain cancer in adults and resultantly has very poor patient outcomes with a median survival rate of only 15 months. To improve treatment success further evaluation of alternative therapies is urgently required. Therefore, we examined the efficacy of an antipsychotic drug olanzapine as an alternative… Read More

DR KAREN MATHER As we age, there is a decline in cognitive performance but there is great variability in the rate and degree of cognitive ageing observed across older adults.  The domains of information processing speed, episodic memory (autobiographical memory) and executive function (decision making) are most affected.  However, the biological processes driving this age-related cognitive decline are unclear.  A greater understanding of the causes and correlates of cognitive ageing would assist in identifying individuals at risk of cognitive decline and suggest interventions that may… Read More