Sydney Memory and Ageing Study

image - DSC 0045 0
Project Main Description: 

The Sydney Memory and Ageing Study (Sydney MAS) began in 2005 to examine the clinical characteristics and prevalence of mild cognitive impairment (MCI) and related syndromes, and to determine the rate of change in cognitive function over time.  It is one of the largest longitudinal studies of this kind in Australia and has resulted in more than 40 scientific publications and many national and international collaborations.

Design and Method: 

At the baseline assessment from 2005 to 2007, 1037 non-demented individuals aged 70-90 were recruited from two areas of Sydney, following a random approach to 8914 individuals on the electoral roll. They underwent detailed neuropsychological and medical assessments and donated a blood sample for clinical chemistry, proteomics and genomics. A knowledgeable informant was also interviewed. Structural MRI scans were performed on 544 of the participants, and subgroups participated in studies of falls and balance, metabolic and inflammatory markers, functional MRI and prospective memory. The group is followed up with brief telephone reviews annually and detailed assessments biannually.

Findings

The Sydney MAS participants are generally well-functioning individuals, mostly living in private homes and rating their health as 'better than average', although vascular risk factors are common.

Most participants (95.5%), or their informants, identified a cognitive difficulty, and 43.5% had impairment on at least one neuropsychological test (Sachdev et al, 2010).

The rate of MCI is relatively high in this population and males have a substantially higher incidence of MCI than females.

Participants with MCI are more likely to develop dementia over the two year follow-up period than those without MCI.

Longitudinal follow-up of this cohort will delineate the progression of complaints and objective impairment, and the determinants of such change.

MAS Published Papers

 

IN PRESS

Authors

Title

Journal

Brodaty H, Mothakunnel A, de Vel-Palumbo M, Ames D, Ellis KA, Reppermund S, Kochan NA, Savage G, Trollor J, Crawford J, Sachdev PS

Influence of population versus convenience sampling on sample characteristics in studies of cognitive aging Annals of Epidemiology (in press)

Callisaya ML, Srikanth VK, Lord SR, Close JC, Brodaty H, Sachdev PS, Phan T, Beare R, Trollor J, Wen W, Zheng JJ, Delbaere K

 Sub-cortical infarcts and the risk of falls in older people: combined results of TASCOG and Sydney MAS studies  International Journal of Stroke (in press)

Ising M, Zimmerman P, Bruckl T, Hohne N, Heck A, Schenk LA, Rejuescu D, Armstrong NJ, Sachdev PS, Reppermund S

Genetic effects on information processing speed are moderated by age - converging results from 3 samples Genes, Brain & Behavior (in press)

Jiang J, Sachdev P, Lipnicki DM, Zhang H, Liu T, Zhu W, Suo C, Zhuang L, Crawford J, Reppermund S, Trollor J, Brodaty H, Wen W

A longitudinal study of brain atrophy over two years in community-dwelling older individuals

 

NeuroImage (in press)

doi:pii: S1053-8119(13)00876-8. 10.1016/j.neuroimage.2013.08.022.

Reppermund S, Zhuang L, Wen W, Slavin MJ, Trollor JN, Brodaty H, Sachdev PS

White matter integrity and late-life depression in community-dwelling individuals. A diffusion tensor imaging study using tract-based spatial statistics

British Journal of Psychiatry (in press)

Smith E, Bailey PE, Crawford J, Samaras K, Baune BT, Campbell L, Menant J, Sturnieks DL, Brodaty H, Sachdev P, Trollor JN

Adiposity estimated by dual energy x-ray absorptiometry and body mass index and its association with cognition in the elderly Journal of American Geriatric Society (in press)

Wong AKW, Lord SR, Trollor JN, Sturnieks DL, Delbaere K, Menant J, Brodaty H, Sachdev PS, Close JCT

Increased arterial pulse wave velocity is a risk factor for falls in community-dwelling older people

Journal of the American Geriatric Society (in press)

Zhang H, Sachdev PS, Wen W, Kochan NA, Crawford JD, Brodaty H, Slavin MJ, Reppermund S, Kang K, Trollor JN

Grey Matter Correlates of Three Language Tests in Non-demented Older Adults

PLOS one (in press)

2014

Authors

Title

Journal

Raamana P, Wen W, Kochan NA, Brodaty H, Sachdev PS, Wang L, Beg M

The sub-classification of amnestic mild cognitive impairment using MRI-based cortical thickness measures

Front. Neurol. 2014; 5: 76

Seeher KM, Low LF, Reppermund S, Slavin MJ, Draper BM, Kang K, Kochan NA, Trollor JN, Sachdev PS, Brodaty H

Correlates of psychological distress in study partners of older people with and without mild cognitive impairment (MCI) - the Sydney Memory and Ageing Study Aging & Mental Health 2014; 18(6): 694-705

Song F, Poljak A, Kochan NA, Raftery M, Brodaty H, Smythe GA, Sachdev PS

 

Plasma protein profiling of Mild Cognitive Impairment and Alzheimer's disease using iTRAQ quantitative proteomics Proteome Science 2014; 12(1): 5

2013

Authors Title

Journal

Brodaty H, Heffernan M, Kochan NA, Draper B, Trollor JN, Reppermund S, Slavin MJ, Sachdev PS

Mild Cognitive Impairment in a community sample: The Sydney Memory and Ageing Study

Alzheimers Dement. 2013 May;9(3):310-317

Fuchs T, Trollor JN, Crawford J, Brown D, Baune BT, Samaras K, Campbell L, Breit SN, Brodaty H,  Sachdev P, Smith E

Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline – the Sydney Memory and Ageing Study

Aging Cell. 2013 Oct;12(5): 882-9

Lipnicki DM, Sachdev PS, Crawford J, Reppermund S, Kochan NA, Trollor JN, Draper B, Slavin MJ, Kang K, Lux O, Mather KA, Brodaty H, and the Sydney Memory and Ageing Study Team

Risk factors for late-life cognitive decline and variation with age and sex in the Sydney Memory and Ageing Study

PLOS one 2013, 8(6): e65841

Liu T, Sachdev PS; Lipnicki DM; Jiang J; Cui Y; Kochan NA; Reppermund S; Trollor JN; Brodaty H, Wen W

Longitudinal changes in sulcal morphology associated with late-life aging and MCI

NeuroImage 2013; 74: 337-342

 

Liu T, Sachdev PS, Lipnicki DM, Jiang J, Geng G, Zhu W, Reppermund S, Tao D, Trollor JN, Brodaty H, Wen W

Limited relationships between two-year changes in sulcal morphology and other common neuroimaging indices in the elderly

Neuroimage 2013 Jun 22;83C:12-17

Menant JC, Wong A, Sturnieks DL, Close JCT, Delbaere K, Sachdev PS, Brodaty H, Lord SR

Pain and anxiety mediate the relationship between dizziness and falls in older people

Journal of the American Geriatric Society 2013 Mar;61(3):423-8

Reppermund S, Brodaty H, Crawford JD, Kochan NA, Draper B, Slavin MJ, Trollor JN, Sachdev PS

Impairment in Instrumental Activities of Daily Living with High Cognitive Demand is an Early Marker of Mild Cognitive Impairment: The Sydney Memory and Ageing Study.

Psychological Medicine 2013 Nov;43(11):2437-45

Sachdev PS, Lipnicki DM, Crawford J, Reppermund S, Kochan NA, Trollor JN, Wen W, Draper B, Slavin MJ, Kang K, Lux O, Mather KA, Brodaty H

Factors predicting reversion from mild cognitive impairment to normal cognitive functioning: a population-based study

PLOS ONE 20138(3):e59649

Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Rockwood K, Xiao S, Li J, Li X, Brayne C, Matthews FE, Stephan BCM, Lipton RB,  Katz MJ, Ritchie K, Carrière I, Ancelin ML, Seshadri S, Au R, Beiser AS, Lam LCW, Wong CHY, Fung AWT, Kim KW, Han JW, Kim TH, Petersen RC, Roberts RO, Mielke MM, Ganguli M,  Dodge H, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Meguro K, Schupf N, Manly J, Stern Y,Lobo A, Lopez-Anton R, Santabárbara J, for COSMIC

COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups BMC Neurology 2013; 13: 165

Schilling S. , DeStefano, A.L.,  Sachdev, P.S. Choi, S.H., Mather, K.A., DeCarli, C.D., Wen, W., Hogh, P., Raz, N., Au, R., Beiser, A.S., Wolf, P.A., Romero, J.R., Zhu, Y-C., Lunetta, K.L., Farrer, L.A., Dufouil, C., Kuller, L.H.,  Mzoyer, B., Seshadri, S., Tzourio, C., Debette, S.

APOE genotype and MRI-markers of cerebrovascular disease:

A systematic review and meta-analysis

Neurology 2013 Jul 16;81(3):292-300

Singer J, Trollor JN, Crawford J, O'Rourke MF, Baune BT, Brodaty H, Samaras K, Kochan NA, Campbell L, Sachdev PS, Smith E.

The Association between Pulse Wave Velocity and Cognitive Function: The Sydney Memory and Ageing Study

PLoS One. 2013 Apr 30;8(4):e61855

Shahnawaz Z, Reppermund S, Brodaty H, Crawford JD, Draper B, Trollor JN, Sachdev PS

Prevalence and Characteristics of Depression in Mild Cognitive Impairment: The Sydney Memory and Ageing Study

Acta Psychiatrica Scandinavica 2013; 127:394-402

Sturnieks DL, Menant J, Delbaere K, Vanrenterghem J, Rogers MW, Fitzpatrick R, Lord SR

Force-controlled balance perturbations associated with falls in older people

PLoS ONE 2013; 8(8): e70981

Tsang RSM, Sachdev PS, Reppermund S, Kochan NA, Kang K, Crawford J, Wen W, Draper B, Trollor JN, Slavin MJ, Mather KA, Assareh A, Seeher KM, Brodaty H

Sydney Memory and Ageing Study: An epidemiological cohort study of brain ageing and dementia International Review of Psychiatry 2013; 25(6): 711-725

Valenzuela MJ, Leon I, Suo C, Piamba DM, Kochan N, Brodaty H, Sachdev P. 

Cognitive lifestyle in older persons: the population-based Sydney Memory and Ageing Study

Journal of Alzheimer’s DiseaseJ Alzheimers Dis. 2013 Jan 1;36(1):87-97.

Wong A, Lord SR, Sturnieks DL, Delbaere K, Trollor JN, Close JCT

Angiotensin System Blocking Medications are Associated with Fewer Falls over 12 Months in Community Dwelling Older People

J Am Geriatr Soc. 2013 May;61(5):776-81

Zhuang L, Sachdev PS, Trollor JN, Reppermund S, Kochan NA, Brodaty H, Wen W

Microstructural white matter changes, not hippocampal atrophy, detect early amnestic mild cognitive impairment

Plos One 2013;8(3):e58887

 2012

Authors

Title

Journal

Baune BT, Smith E, Reppermund S, Air T, Samaras K, Lux O, Brodaty H, Sachdev P, Trollor JN

Inflammatory biomarkers predict Depression, but not Anxiety during Aging: The Prospective Sydney Memory and Aging Study

Psychoneuroendocrinology 2012 Sep;37(9):1521-30.

Brodaty H, Heffernan M, Kochan NA, Draper B, Trollor JN, Reppermund S, Slavin MJ, Sachdev PS

Neuropsychiatric symptoms in older people with and without cognitive impairment

Journal of Alzheimer’s Disease 2012;31: 411–420

Cui Y, Sachdev PS, Lipnicki DM, Jin JS, Luo S, Zhu W, Kochan NA, Reppermund S, Liu T, Trollor JN, Brodaty H, Wen W

Predicting the development of mild cognitive impairment: A new use of pattern recognition

Neuroimage. 2012 Jan 25;60(2):894-901

Cui Y, Wen W, Lipnicki DM, Beg MF, Jin JS, Luo S, Zhu W, Kochan NA, Reppermund S, Zhuang L, Ramana PR, Liu T, Trollor JN, Wang L, Brodaty H, Sachdev PS

Automated detection of amnestic mild cognitive impairment in community-dwelling elderly adults: a combined spatial atrophy and white matter alteration approach

Neuroimage. 2012 Jan 16;59(2):1209-17

Delbaere K, Kochan NA, Close JC, Menant JC, Sturnieks DL, Brodaty H, Sachdev PS, Lord SR

Mild cognitive impairment as a predictor of falls in community-dwelling older people

Am J Geriatr Psychiatry. 2012 Oct;20(10):845-853

Delbaere K, Close JC,  Kochan NA, Sachdev PS, Lord SR

Good memory as a predictor of falls: FACT or artefact

Age Ageing 2012; 41(3):404-8.

Haerer W, Delbaere K, Lord SR, Rowland, J

Relationships Between Hmg-Coa Reductase Inhibitors (Statin) Use and Strength, Balance and Falls in Older People

Internal Medicine Journal. 2012 Dec;42(12):1329-34.

Henry JD, Thompson C, Rendel PG, Phillips LH, Carbert J, Sachdev P, Brodaty H

Perception of biological motion and emotion in mild cognitive impairment and dementia

Journal of the International Neuropsychological Society 2012 Sep;18(5):866-73

Low L-F, Harrison F, Kochan NA, Draper B, Slavin MJ, Reppermund S, Sachdev PS, Brodaty H

Can Mild Cognitive Impairment be accurately diagnosed in English speakers from linguistic minorities? Results from the Sydney Memory and Ageing Study.

Am J Geriatr Psychiatry. 2012 Oct;20(10):866-77

Menant JC, Close JC, Delbaere K, Sturnieks DL, Trollor J, Sachdev PS, Brodaty H, Lord SR

Relationships between serum vitamin D levels, neuromuscular and neuropsychological function and falls in older men and women.

Osteoporos Int. 2012 Mar;23(3):981-9

Sachdev PS, Lipnicki DM, Crawford J, Reppermund S, Kochan NA, Trollor JN, Draper B, Slavin MJ, Kang K, Lux O, Mather KA, Brodaty H, and the Sydney Memory and Ageing Study Team

Risk profiles for mild cognitive impairment vary by age and sex: The Sydney Memory and Ageing Study

Am J Geriatr Psychiatry. 2012 Oct;20(10):854-865

Sachdev PS, Lipnicki DM, Crawford J, Reppermund S, Kochan NA, Trollor JN, Draper B, Slavin MJ, Kang K, Lux O, Mather KA, Brodaty H and the Memory and Ageing Study Team

Risk profiles of subtypes of mild cognitive impairment: The Sydney Memory and Ageing Study

J Am Geriatr Soc. 2012 Jan;60(1):24-33

Samaras K, Trollor J, Sachdev P, Brodaty H, Smith E, Campbell L, Baune B,  Lux O, Crawford J

The Value of the Metabolic Syndrome Concept in Elderly Adults: Is It Worth Less Than the Sum of Its Parts?

J Am Geriatr Soc. 2012 Sep;60(9):1734-41

Song F, Poljak A, Crawford J, Kochan NA, Wen W , Cameron B, Lux O, Brodaty H, Mather K, Smythe GA,  Sachdev PS

Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals

PLOS one 2012;7(6):e3407

Sturnieks D, Menant J, Vanrenterghem J, Delbaere K, Fitzpatrick RC, Lord S

Sensorimotor and Neuropsychological Correlates of Force Perturbations that Induce Stepping in Older Adults

Gait and Posture 2012;36(3):356-60

Suo C, Leon I, Brodaty H, Trollor J, Wen W, Sachdev P, Valenzuela M

Supervisory Experience at Work is Linked to Low Rate of Hippocampal Atrophy in Late Life

Neuroimage. 2012 Aug 12;63(3):1542-1551

Thillainadesan S, Wen W, Zhuang L, Crawford J, Kochan N, Reppermund S, Slavin M, Trollor J, Brodaty H, Sachdev P

Changes in Mild Cognitive Impairment and its subtypes as seen on Diffusion Tensor Imaging

International Psychogeriatrics 2012; 24(9):1483-1493

Trollor JN, Smith E, Agars E, Kuan SA, Baune BT, Campbell L, Samaras K, Crawford J, Lux O, Kochan NA, Brodaty H, Sachdev P.

The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study.

Age (Dordr). 2012 Oct;34(5):1295-308.

Zhang H, Trollor JN, Wen W, Kochan NA, Crawford JD, Brodaty H, Slavin MJ, Reppermund S, Draper B, Zhu W, Kang K, Sachdev PS

Gray Matter Atrophy Patterns of Mild Cognitive Impairment Subtypes

Journal of the Neurological Sciences 2012, 315: 26–32

Zheng JJ, Delbaere K, Close JC, Sachdev PS, Wen W, Brodaty H, Lord SR

White Matter Hyperintensities Are an Independent Predictor of Physical Decline in Community-Dwelling Older People

Gerontology 2012;58(5):398-406

Zheng JJ, Lord SR, Close JC, Sachdev PS, Wen W, Brodaty H, Delbaere K

Brain white matter hyperintensities, executive dysfunction, instability and falls in older people: a prospective cohort study

J Gerontol A Biol Sci Med Sci.2012 Oct;67(10):1085-91

Zheng JJ, Delbaere K, Close JCT, Sachdev PS, Wen W, Lord SR

White matter hyperintensities and impaired choice stepping reaction time in older people

Neurobiol Aging. 2012;33(7):1177-85

Zhuang L, Sachdev P, Trollor J, Kochan N, Reppermund S, Brodaty H, Wen W.

Microstructural white matter changes in cognitively normal individuals at risk of amnestic MCI

Neurology 2012 Aug 21;79(8):748-54

Zhuang L, Wen W, Trollor JN, Kochan NA, Reppermund S, Brodaty H, Sachdev PS

Abnormalities of the fornix in Mild Cognitive Impairment are related to episodic memory loss

Journal of Alzheimer’s Disease 2012, 28, 1-11

2011

Authors

Title

Journal

Liu T, Wen W, Zhu W, Kochan NA, Trollor JN, Reppermund S, Jin JS, Luo S, Brodaty H, Sachdev PS

The relationship between cortical sulcal variability and cognitive performance in the elderly.

Neuroimage 2011; 56, 865-873

Kochan NA, Breakspear M, Valenzuela M, Slavin MJ, Brodaty H, Wen W, Trollor JN, Turner A, Crawford JD, Sachdev PS

Cortical Responses to a Graded Working Memory Challenge Predict Functional Decline in Mild Cognitive Impairment

Biological Psychiatry 2011 70(2):123-30

Reppermund S, Brodaty H, Crawford JD, Kochan NA, Slavin MJ, Trollor JN, Draper B, Sachdev PS

The relationship of current depressive symptoms and past depression with cognitive impairment and instrumental activities of daily living in an elderly population:  the Sydney Memory and Ageing Study

Journal of Psychiatric Research 2011; 45(12):1600-7

Reppermund S, Sachdev PS, Crawford J, Kochan NA, Slavin MJ, Kang K, Trollor JN, Draper B, Brodaty H.

The relationship of neuropsychological function to instrumental activities of daily living in mild cognitive impairment

Int J Geriatr Psychiatry. 2011; 26(8):843-52

Wen W, Zhu W, He Y, Kochan NA, Reppermund S, Slavin MJ, Brodaty H, Crawford J, Xia A, Sachdev P

Discrete Neuroanatomical Networks Are Associated with Specific Cognitive Abilities in Old Age

J Neurosci. 2011;31(4):1204-1212

Zhang H, Trollor JN, Wen W, Zhu W, Crawford JD, Kochan NA, Slavin MJ, Brodaty H, Reppermund S, Kang K, Mather KA, Sachdev PS

Gray matter atrophy of basal forebrain and hippocampus in mild cognitive impairment

J Neurol Neurosurg Psychiatry. 2011 May;82(5):487-93

Zhang H, Sachdev PS, Wen W, Kochan NA, Zhu W, Crawford JD, Brodaty H, Slavin MJ, Reppermund S, Kang K, Trollor JN

Neuroanatomical correlates of cognitive performance in late life

Dement Geriatr Cogn Disord. 2011;32:216-226

Zheng JJ, Delbaere K, Close JC, Sachdev PS, Lord SR.

Impact of white matter lesions on physical functioning and fall risk in older people: a systematic review.

Stroke. 2011 Jul;42(7):2086-90

2010

Authors

Title

Journal

Delbaere K, Close JC, Heim J, Sachdev PS, Brodaty H, Slavin MJ, Kochan NA, Lord SR

A multifactorial approach to understanding fall risk in older people

J Am Geriatr Soc. 2010;58 (9):1679-85.

Delbaere K, Close JC, Brodaty H, Sachdev P, Lord SR

Determinants of disparities between perceived and physiological risk of falling among elderly people: cohort study

BMJ. 2010 Aug 18;341:c4165

Delbaere K, Close JC, Mikolaizak AS, Sachdev PS, Brodaty H, Lord SR

The Falls Efficacy Scale International (FES-I). A comprehensive longitudinal validation study

Age Ageing. 2010 Mar;39(2):210-6

Kochan NA, Slavin MJ, Brodaty H, Crawford JD, Trollor JN, Draper B, Sachdev PS

Effect of Different Impairment Criteria on Prevalence of ‘Objective’ Mild Cognitive Impairment in a Community Sample

AJGP 2010; 18: 711-722

Kochan NA, Breakspear M, Slavin MJ, Valenzuela M, McCraw S, Brodaty H, Sachdev PS

Functional alterations in brain activation and deactivation in mild cognitive impairment in response to a graded working memory challenge

Dement Geriatr Cogn Disord. 2010;30(6):553-68

Liu T, Wen W, Zhu W, Trollor J, Reppermund S, Crawford J, Jin JS, Luo S, Brodaty H, Sachdev P

The effects of age and sex on cortical sulci in the elderly

Neuroimage 2010;51(1):19-27

Sachdev PS, Brodaty H, Reppermund S, Kochan NA, Trollor JN, Draper B, Slavin MJ, Crawford J, Kang K, Broe GA, Mather KA, Lux O; Memory and Ageing Study Team

The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years

Int Psychogeriatr. 2010;22(8):1248-64

Slavin MJ, Brodaty H, Kochan NA, Crawford JD, Trollor JN, Draper B, Sachdev PS

Prevalence and Predictors of 'Subjective Cognitive Complaints' in the Sydney Memory and Ageing Study

AJGP - 2010; 18: 701-710

Trollor JN, Smith E, Baune BT, Kochan NA, Campbell L, Samaras K, Crawford J, Brodaty H, Sachdev P.

Systemic Inflammation Is Associated with MCI and Its Subtypes: The Sydney Memory and Aging Study.

Dement Geriatr Cogn Disord. 2010;30(6):569-78

Zhuang L, Wen W, Zhu W, Trollor J, Kochan N, Crawford J, Reppermund S, Brodaty H, Sachdev P.

White matter integrity in mild cognitive impairment: a tract-based spatial statistics study.

Neuroimage. 2010 Oct 15;53(1):16-25

2009

Authors

Title

Journal

Chua TC, Wen W, Chen X, Kochan N, Slavin MJ, Trollor JN, Brodaty H, Sachdev PS

Diffusion tensor imaging of the posterior cingulate is a useful biomarker of mild cognitive impairment

Am J Geriatr Psychiatry. 2009;17(7):602-13

Delbaere K, Sturnieks DL, Crombez G, Lord SR

Concern About Falls Elicits Changes in Gait Parameters in Conditions of Postural Threat in Older People

J Gerontol A Biol Sci Med Sci 2009; 64, No. 2, 237–242

 

Project Status: 
Current
Back to Top