Defining the Role of Inflammation in Depression during Ageing

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Project Main Description: 

The relationship between inflammation and geriatric depression is well-established, and offers the potential for the development of novel therapeutic strategies based on inflammatory targets. However, the relationship between depression and inflammation is complicated by age-associated factors (e.g. cardiovascular diseases, metabolic changes, morphological brain changes) which may contribute to both inflammation and depressive symptoms. It is therefore not yet known if inflammation is a cause or consequence, or both, of geriatric depression.

Aims: 
  1. To understand the relationship between inflammation and depression during ageing, through the investigation of the bidirectional relationship between inflammatory biomarkers in the Sydney Memory & Ageing Study (MAS).

  2. To investigate the molecular underpinnings of inflammation during ageing by analysing genetic, gene expression, and protein biomarkers.

  3. To develop an inflammation-based prediction model of depression (consisting of clinical, genetic, gene expression and protein biomarkers in the context of inflammation) during ageing in the MAS (discovery sample) and to replicate in a second ageing sample, the Older Australian Twins Study (OATS).

Project Status: 
Current
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