Principal Investigator
Professor Hugh Stephen Markus
University of Cambridge
Department of Clinical Neurosciences
Neurology Unit
Telephone number (+44) 01223 586661
Summary
Country | UK |
---|---|
Principal Investigator | Professor Hugh Stephen Markus |
Contact person (email) | hsm32@medschl.cam.ac.uk |
Key publication/reference | Lawrence et al. PLoS One 2015: e0135523 |
Years in which study conducted | Recruited 2007-10. Last follow-up 2015 |
Sample | |
Size | 121 |
Population: Hospital/community | Hospital |
Selection: consecutive/random | Consecutive SVD cases agreeing to participate |
Admit with previous stroke? | Yes |
Admit with TIA? | Yes but only if corresponding lacunar infarct |
Age range | 18+ |
Number of centres | 1 |
Control group: number, population, selection | Yes |
Assessment | |
Initial assessment | At least 3 months post last stroke |
First detailed assessment | Baseline |
Follow-ups | Annually for 5 years |
Stroke-related data | Recurrent strokes |
Functional tests/data | GWAS on most |
Other medical tests/data | Cardiovascular risk factors |
Neuropsychological tests | Extensive screen |
MRI scans, when and how many | Annual MRI at baseline and years 1,2,3 |
PET scans | No |
Psychiatric exams | GDS |
Dementia diagnosis criteria | Diagnostic and Statistical Manual of Mental Disorders V (DSM-V) (American Psychiatric Association, 2013) definition of "major neurocognitive disorder" |
Intervention trialled? | No |